Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle dr...

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Autores principales:	Michael F. Cuccarese, J. Matthew Dubach, Christina Pfirschke, Camilla Engblom, Christopher Garris, Miles A. Miller, Mikael J. Pittet, Ralph Weissleder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3110620e30e417bbd3502f5ec747b02
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spelling	oai:doaj.org-article:a3110620e30e417bbd3502f5ec747b022021-12-02T17:06:02ZHeterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging10.1038/ncomms142932041-1723https://doaj.org/article/a3110620e30e417bbd3502f5ec747b022017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14293https://doaj.org/toc/2041-1723Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle drug delivery.Michael F. CuccareseJ. Matthew DubachChristina PfirschkeCamilla EngblomChristopher GarrisMiles A. MillerMikael J. PittetRalph WeisslederNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael F. Cuccarese J. Matthew Dubach Christina Pfirschke Camilla Engblom Christopher Garris Miles A. Miller Mikael J. Pittet Ralph Weissleder Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
description	Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle drug delivery.
format	article
author	Michael F. Cuccarese J. Matthew Dubach Christina Pfirschke Camilla Engblom Christopher Garris Miles A. Miller Mikael J. Pittet Ralph Weissleder
author_facet	Michael F. Cuccarese J. Matthew Dubach Christina Pfirschke Camilla Engblom Christopher Garris Miles A. Miller Mikael J. Pittet Ralph Weissleder
author_sort	Michael F. Cuccarese
title	Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
title_short	Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
title_full	Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
title_fullStr	Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
title_full_unstemmed	Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging
title_sort	heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3d organ imaging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3110620e30e417bbd3502f5ec747b02
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Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

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