Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density

Abstract Mammographic breast density (MBD) is a strong independent risk factor for breast cancer (BC). We designed a matched case–case study in the EPIC Florence cohort, to evaluate possible associations between the pre-diagnostic metabolomic profile and the risk of BC in high- versus low-MBD women...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Benedetta Bendinelli, Alessia Vignoli, Domenico Palli, Melania Assedi, Daniela Ambrogetti, Claudio Luchinat, Saverio Caini, Calogero Saieva, Paola Turano, Giovanna Masala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a312cd504eb74c948dcfb825e52ec742
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a312cd504eb74c948dcfb825e52ec742
record_format	dspace
spelling	oai:doaj.org-article:a312cd504eb74c948dcfb825e52ec7422021-12-02T17:12:21ZPrediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density10.1038/s41598-021-92508-12045-2322https://doaj.org/article/a312cd504eb74c948dcfb825e52ec7422021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92508-1https://doaj.org/toc/2045-2322Abstract Mammographic breast density (MBD) is a strong independent risk factor for breast cancer (BC). We designed a matched case–case study in the EPIC Florence cohort, to evaluate possible associations between the pre-diagnostic metabolomic profile and the risk of BC in high- versus low-MBD women who developed BC during the follow-up. A case–case design with 100 low-MBD (MBD ≤ 25%) and 100 high-MDB BC cases (MBD > 50%) was performed. Matching variables included age, year and type of mammographic examination. 1H NMR metabolomic spectra were available for 87 complete case–case sets. The conditional logistic analyses showed an inverse association between serum levels of alanine, leucine, tyrosine, valine, lactic acid, pyruvic acid, triglycerides lipid main fraction and 11 VLDL lipid subfractions and high-MBD cases. Acetic acid was directly associated with high-MBD cases. In models adjusted for confounding variables, tyrosine remained inversely associated with high-MBD cases while 3 VLDL subfractions of free cholesterol emerged as directly associated with high-MBD cases. A pathway analysis showed that the “phenylalanine, tyrosine and tryptophan pathway” emerged and persisted after applying the FDR procedure. The supervised OPLS-DA analysis revealed a slight but significant separation between high- and low-MBD cases. This case–case study suggested a possible role for pre-diagnostic levels of tyrosine in modulating the risk of BC in high- versus low-MBD women. Moreover, some differences emerged in the pre-diagnostic concentration of other metabolites as well in the metabolomic fingerprints among the two groups of patients.Benedetta BendinelliAlessia VignoliDomenico PalliMelania AssediDaniela AmbrogettiClaudio LuchinatSaverio CainiCalogero SaievaPaola TuranoGiovanna MasalaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benedetta Bendinelli Alessia Vignoli Domenico Palli Melania Assedi Daniela Ambrogetti Claudio Luchinat Saverio Caini Calogero Saieva Paola Turano Giovanna Masala Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density
description	Abstract Mammographic breast density (MBD) is a strong independent risk factor for breast cancer (BC). We designed a matched case–case study in the EPIC Florence cohort, to evaluate possible associations between the pre-diagnostic metabolomic profile and the risk of BC in high- versus low-MBD women who developed BC during the follow-up. A case–case design with 100 low-MBD (MBD ≤ 25%) and 100 high-MDB BC cases (MBD > 50%) was performed. Matching variables included age, year and type of mammographic examination. 1H NMR metabolomic spectra were available for 87 complete case–case sets. The conditional logistic analyses showed an inverse association between serum levels of alanine, leucine, tyrosine, valine, lactic acid, pyruvic acid, triglycerides lipid main fraction and 11 VLDL lipid subfractions and high-MBD cases. Acetic acid was directly associated with high-MBD cases. In models adjusted for confounding variables, tyrosine remained inversely associated with high-MBD cases while 3 VLDL subfractions of free cholesterol emerged as directly associated with high-MBD cases. A pathway analysis showed that the “phenylalanine, tyrosine and tryptophan pathway” emerged and persisted after applying the FDR procedure. The supervised OPLS-DA analysis revealed a slight but significant separation between high- and low-MBD cases. This case–case study suggested a possible role for pre-diagnostic levels of tyrosine in modulating the risk of BC in high- versus low-MBD women. Moreover, some differences emerged in the pre-diagnostic concentration of other metabolites as well in the metabolomic fingerprints among the two groups of patients.
format	article
author	Benedetta Bendinelli Alessia Vignoli Domenico Palli Melania Assedi Daniela Ambrogetti Claudio Luchinat Saverio Caini Calogero Saieva Paola Turano Giovanna Masala
author_facet	Benedetta Bendinelli Alessia Vignoli Domenico Palli Melania Assedi Daniela Ambrogetti Claudio Luchinat Saverio Caini Calogero Saieva Paola Turano Giovanna Masala
author_sort	Benedetta Bendinelli
title	Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density
title_short	Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density
title_full	Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density
title_fullStr	Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density
title_full_unstemmed	Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density
title_sort	prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a312cd504eb74c948dcfb825e52ec742
work_keys_str_mv	AT benedettabendinelli prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT alessiavignoli prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT domenicopalli prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT melaniaassedi prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT danielaambrogetti prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT claudioluchinat prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT saveriocaini prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT calogerosaieva prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT paolaturano prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity AT giovannamasala prediagnosticcirculatingmetabolitesinfemalebreastcancercaseswithlowandhighmammographicbreastdensity
_version_	1718381451744903168

Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density

Ejemplares similares