IMMUNITY ACTIVATION IN HIV INFECTION

This review article concerns a challenging problem of HIV infection, immune activation. The processes of immune activation largely determine CD4+T cell depletion, leading to development of AIDS-associated and non-AIDS-related diseases. Immune activation indices are also strong predictors of the clin...

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Autores principales:	K. V. Shmagel, N. G. Shmagel, V. A. Chereshnev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	hiv infection immune activation inflammation lymphopenia cytokines microbial translocation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a3135c4618c843c2ad078e182f30328e
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spelling	oai:doaj.org-article:a3135c4618c843c2ad078e182f30328e2021-11-18T08:03:46ZIMMUNITY ACTIVATION IN HIV INFECTION1563-06252313-741X10.15789/1563-0625-2017-5-489-504https://doaj.org/article/a3135c4618c843c2ad078e182f30328e2017-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1348https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThis review article concerns a challenging problem of HIV infection, immune activation. The processes of immune activation largely determine CD4+T cell depletion, leading to development of AIDS-associated and non-AIDS-related diseases. Immune activation indices are also strong predictors of the clinical outcome. Activation in HIV-infection affects both innate and adaptive immune cells, leads to increased proinflammatory cytokine production and blood coagulation. The reasons for immune activation may include different pathogens (HIV, cytomegalovirus, Epstein–Barr virus, hepatitis C virus), lymphopenia and lymphopenia-induced T lymphocyte homeostatic proliferation, transfer of microbial products from the gut, due to profound CD4+T cell deficiency in lamina propria and altered permeability of intestinal barrier. Other factors that promote the process of immune activation are as follows: T lymphocyte "bystander" activation, increased T cell turnover, and systemic inflammation development. The review covers pathogenic mechanisms HIV-infection associated with immune activation, like as description of different laboratory parameters characterizing its manifestations in HIV-infected patients. Significance and prognostic role of these parameters in assessing efficiency of antiretroviral therapy, development of complications, and adverse outcomes of infection are presented as well.K. V. ShmagelN. G. ShmagelV. A. ChereshnevSPb RAACIarticlehiv infectionimmune activationinflammationlymphopeniacytokinesmicrobial translocationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 5, Pp 489-504 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv infection immune activation inflammation lymphopenia cytokines microbial translocation Immunologic diseases. Allergy RC581-607
spellingShingle	hiv infection immune activation inflammation lymphopenia cytokines microbial translocation Immunologic diseases. Allergy RC581-607 K. V. Shmagel N. G. Shmagel V. A. Chereshnev IMMUNITY ACTIVATION IN HIV INFECTION
description	This review article concerns a challenging problem of HIV infection, immune activation. The processes of immune activation largely determine CD4+T cell depletion, leading to development of AIDS-associated and non-AIDS-related diseases. Immune activation indices are also strong predictors of the clinical outcome. Activation in HIV-infection affects both innate and adaptive immune cells, leads to increased proinflammatory cytokine production and blood coagulation. The reasons for immune activation may include different pathogens (HIV, cytomegalovirus, Epstein–Barr virus, hepatitis C virus), lymphopenia and lymphopenia-induced T lymphocyte homeostatic proliferation, transfer of microbial products from the gut, due to profound CD4+T cell deficiency in lamina propria and altered permeability of intestinal barrier. Other factors that promote the process of immune activation are as follows: T lymphocyte "bystander" activation, increased T cell turnover, and systemic inflammation development. The review covers pathogenic mechanisms HIV-infection associated with immune activation, like as description of different laboratory parameters characterizing its manifestations in HIV-infected patients. Significance and prognostic role of these parameters in assessing efficiency of antiretroviral therapy, development of complications, and adverse outcomes of infection are presented as well.
format	article
author	K. V. Shmagel N. G. Shmagel V. A. Chereshnev
author_facet	K. V. Shmagel N. G. Shmagel V. A. Chereshnev
author_sort	K. V. Shmagel
title	IMMUNITY ACTIVATION IN HIV INFECTION
title_short	IMMUNITY ACTIVATION IN HIV INFECTION
title_full	IMMUNITY ACTIVATION IN HIV INFECTION
title_fullStr	IMMUNITY ACTIVATION IN HIV INFECTION
title_full_unstemmed	IMMUNITY ACTIVATION IN HIV INFECTION
title_sort	immunity activation in hiv infection
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/a3135c4618c843c2ad078e182f30328e
work_keys_str_mv	AT kvshmagel immunityactivationinhivinfection AT ngshmagel immunityactivationinhivinfection AT vachereshnev immunityactivationinhivinfection
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IMMUNITY ACTIVATION IN HIV INFECTION

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