Structure of a Wbl protein and implications for NO sensing by M. tuberculosis

Mycobacterium tuberculosis WhiB1 is a DNA-binding protein with a NO sensitive [4Fe-4S] cluster. Here the authors present the NMR structure of WhiB1 and suggest how loss of the iron-sulfur cluster through nitrosylation affects WhiB1 DNA binding and leads to transcriptional reprogramming.

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Autores principales:	Bassam K. Kudhair, Andrea M. Hounslow, Matthew D. Rolfe, Jason C. Crack, Debbie M. Hunt, Roger S. Buxton, Laura J. Smith, Nick E. Le Brun, Michael P. Williamson, Jeffrey Green
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3161fc00cf1472d8753db514aa76e06
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spelling	oai:doaj.org-article:a3161fc00cf1472d8753db514aa76e062021-12-02T14:41:20ZStructure of a Wbl protein and implications for NO sensing by M. tuberculosis10.1038/s41467-017-02418-y2041-1723https://doaj.org/article/a3161fc00cf1472d8753db514aa76e062017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02418-yhttps://doaj.org/toc/2041-1723Mycobacterium tuberculosis WhiB1 is a DNA-binding protein with a NO sensitive [4Fe-4S] cluster. Here the authors present the NMR structure of WhiB1 and suggest how loss of the iron-sulfur cluster through nitrosylation affects WhiB1 DNA binding and leads to transcriptional reprogramming.Bassam K. KudhairAndrea M. HounslowMatthew D. RolfeJason C. CrackDebbie M. HuntRoger S. BuxtonLaura J. SmithNick E. Le BrunMichael P. WilliamsonJeffrey GreenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bassam K. Kudhair Andrea M. Hounslow Matthew D. Rolfe Jason C. Crack Debbie M. Hunt Roger S. Buxton Laura J. Smith Nick E. Le Brun Michael P. Williamson Jeffrey Green Structure of a Wbl protein and implications for NO sensing by M. tuberculosis
description	Mycobacterium tuberculosis WhiB1 is a DNA-binding protein with a NO sensitive [4Fe-4S] cluster. Here the authors present the NMR structure of WhiB1 and suggest how loss of the iron-sulfur cluster through nitrosylation affects WhiB1 DNA binding and leads to transcriptional reprogramming.
format	article
author	Bassam K. Kudhair Andrea M. Hounslow Matthew D. Rolfe Jason C. Crack Debbie M. Hunt Roger S. Buxton Laura J. Smith Nick E. Le Brun Michael P. Williamson Jeffrey Green
author_facet	Bassam K. Kudhair Andrea M. Hounslow Matthew D. Rolfe Jason C. Crack Debbie M. Hunt Roger S. Buxton Laura J. Smith Nick E. Le Brun Michael P. Williamson Jeffrey Green
author_sort	Bassam K. Kudhair
title	Structure of a Wbl protein and implications for NO sensing by M. tuberculosis
title_short	Structure of a Wbl protein and implications for NO sensing by M. tuberculosis
title_full	Structure of a Wbl protein and implications for NO sensing by M. tuberculosis
title_fullStr	Structure of a Wbl protein and implications for NO sensing by M. tuberculosis
title_full_unstemmed	Structure of a Wbl protein and implications for NO sensing by M. tuberculosis
title_sort	structure of a wbl protein and implications for no sensing by m. tuberculosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3161fc00cf1472d8753db514aa76e06
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Structure of a Wbl protein and implications for NO sensing by M. tuberculosis

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