Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition

Immunopeptidomics allows identifying the cellular repertoire of MHC-bound peptides, but quantifying them remains challenging. Here, the authors present a method to efficiently generate internal peptide MHC standards and calibration curves, facilitating relative and absolute quantitative immunopeptid...

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Autores principales:	Lauren E. Stopfer, Joshua M. Mesfin, Brian A. Joughin, Douglas A. Lauffenburger, Forest M. White
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a31704ed76cf4812b9becfece7121839
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spelling	oai:doaj.org-article:a31704ed76cf4812b9becfece71218392021-12-02T17:51:27ZMultiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition10.1038/s41467-020-16588-92041-1723https://doaj.org/article/a31704ed76cf4812b9becfece71218392020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16588-9https://doaj.org/toc/2041-1723Immunopeptidomics allows identifying the cellular repertoire of MHC-bound peptides, but quantifying them remains challenging. Here, the authors present a method to efficiently generate internal peptide MHC standards and calibration curves, facilitating relative and absolute quantitative immunopeptidomics.Lauren E. StopferJoshua M. MesfinBrian A. JoughinDouglas A. LauffenburgerForest M. WhiteNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauren E. Stopfer Joshua M. Mesfin Brian A. Joughin Douglas A. Lauffenburger Forest M. White Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition
description	Immunopeptidomics allows identifying the cellular repertoire of MHC-bound peptides, but quantifying them remains challenging. Here, the authors present a method to efficiently generate internal peptide MHC standards and calibration curves, facilitating relative and absolute quantitative immunopeptidomics.
format	article
author	Lauren E. Stopfer Joshua M. Mesfin Brian A. Joughin Douglas A. Lauffenburger Forest M. White
author_facet	Lauren E. Stopfer Joshua M. Mesfin Brian A. Joughin Douglas A. Lauffenburger Forest M. White
author_sort	Lauren E. Stopfer
title	Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition
title_short	Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition
title_full	Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition
title_fullStr	Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition
title_full_unstemmed	Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition
title_sort	multiplexed relative and absolute quantitative immunopeptidomics reveals mhc i repertoire alterations induced by cdk4/6 inhibition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a31704ed76cf4812b9becfece7121839
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Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition

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