A comprehensive overview of genomic imprinting in breast and its deregulation in cancer

In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer dat...

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Autores principales:	Tine Goovaerts, Sandra Steyaert, Chari A. Vandenbussche, Jeroen Galle, Olivier Thas, Wim Van Criekinge, Tim De Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a31747ded3ca420d952e1b5d3be9291b
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spelling	oai:doaj.org-article:a31747ded3ca420d952e1b5d3be9291b2021-12-02T16:49:55ZA comprehensive overview of genomic imprinting in breast and its deregulation in cancer10.1038/s41467-018-06566-72041-1723https://doaj.org/article/a31747ded3ca420d952e1b5d3be9291b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06566-7https://doaj.org/toc/2041-1723In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer data they find massive deregulation of imprinting.Tine GoovaertsSandra SteyaertChari A. VandenbusscheJeroen GalleOlivier ThasWim Van CriekingeTim De MeyerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tine Goovaerts Sandra Steyaert Chari A. Vandenbussche Jeroen Galle Olivier Thas Wim Van Criekinge Tim De Meyer A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
description	In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer data they find massive deregulation of imprinting.
format	article
author	Tine Goovaerts Sandra Steyaert Chari A. Vandenbussche Jeroen Galle Olivier Thas Wim Van Criekinge Tim De Meyer
author_facet	Tine Goovaerts Sandra Steyaert Chari A. Vandenbussche Jeroen Galle Olivier Thas Wim Van Criekinge Tim De Meyer
author_sort	Tine Goovaerts
title	A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_short	A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_full	A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_fullStr	A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_full_unstemmed	A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_sort	comprehensive overview of genomic imprinting in breast and its deregulation in cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a31747ded3ca420d952e1b5d3be9291b
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A comprehensive overview of genomic imprinting in breast and its deregulation in cancer

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