Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction

Abstract The objective of this study is to explore whether procalcitonin (PCT) can serve as an early biomarker of malignant cerebral edema in patients with massive cerebral infarction (MCI). Ninety-three patients with acute MCI were divided into death or survival groups based on whether they died or...

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Autores principales:	Yan Zhang, Gang Liu, Yuan Wang, Yingying Su, Rehana K. Leak, Guodong Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a318188482ab475495017ca01732f8fa
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spelling	oai:doaj.org-article:a318188482ab475495017ca01732f8fa2021-12-02T15:08:39ZProcalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction10.1038/s41598-018-19267-42045-2322https://doaj.org/article/a318188482ab475495017ca01732f8fa2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19267-4https://doaj.org/toc/2045-2322Abstract The objective of this study is to explore whether procalcitonin (PCT) can serve as an early biomarker of malignant cerebral edema in patients with massive cerebral infarction (MCI). Ninety-three patients with acute MCI were divided into death or survival groups based on whether they died or survived within 1 week of cerebral herniation. Differences in laboratory parameters between these two groups were analyzed by univariate analysis, followed by multivariate logistic regression analyses if the influencing factors were significantly different. Compared with the survival group, the patients in the death group had a larger cerebral infarct area, higher body temperature, neutrophil counts, PCT level, and neuron-specific enolase (NSE) level within 48 h of onset. Multivariate logistic regression analyses revealed an odds ratio (OR) of 1.830 or 1.235 for PCT and neutrophil counts respectively, suggesting that PCT and neutrophil counts are two independent risk factors for death in MCI. The area under receiver operating characteristic (ROC) curve was 0.754 for PCT, larger than that for neutrophil counts. Thus, both serum PCT levels and neutrophil counts can be used as biomarkers to predict malignant cerebral edema at the early stages after MCI, but PCT levels are superior predictors of malignant cerebral edema.Yan ZhangGang LiuYuan WangYingying SuRehana K. LeakGuodong CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Zhang Gang Liu Yuan Wang Yingying Su Rehana K. Leak Guodong Cao Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction
description	Abstract The objective of this study is to explore whether procalcitonin (PCT) can serve as an early biomarker of malignant cerebral edema in patients with massive cerebral infarction (MCI). Ninety-three patients with acute MCI were divided into death or survival groups based on whether they died or survived within 1 week of cerebral herniation. Differences in laboratory parameters between these two groups were analyzed by univariate analysis, followed by multivariate logistic regression analyses if the influencing factors were significantly different. Compared with the survival group, the patients in the death group had a larger cerebral infarct area, higher body temperature, neutrophil counts, PCT level, and neuron-specific enolase (NSE) level within 48 h of onset. Multivariate logistic regression analyses revealed an odds ratio (OR) of 1.830 or 1.235 for PCT and neutrophil counts respectively, suggesting that PCT and neutrophil counts are two independent risk factors for death in MCI. The area under receiver operating characteristic (ROC) curve was 0.754 for PCT, larger than that for neutrophil counts. Thus, both serum PCT levels and neutrophil counts can be used as biomarkers to predict malignant cerebral edema at the early stages after MCI, but PCT levels are superior predictors of malignant cerebral edema.
format	article
author	Yan Zhang Gang Liu Yuan Wang Yingying Su Rehana K. Leak Guodong Cao
author_facet	Yan Zhang Gang Liu Yuan Wang Yingying Su Rehana K. Leak Guodong Cao
author_sort	Yan Zhang
title	Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction
title_short	Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction
title_full	Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction
title_fullStr	Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction
title_full_unstemmed	Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction
title_sort	procalcitonin as a biomarker for malignant cerebral edema in massive cerebral infarction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a318188482ab475495017ca01732f8fa
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Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction

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