Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish

A small percentage of cardiomyocytes (CM) are of neural crest origin but the function of such cells in the adult zebrafish is unclear. Here, the authors identify this CM subpopulation as expressing the Notch ligand jag2b and if deleted in the embryo, cause severe hypertrophic cardiomyopathy in adult...

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Autores principales:	Sarah Abdul-Wajid, Bradley L. Demarest, H. Joseph Yost
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a31b2588da5a4210aa43a02306851e34
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spelling	oai:doaj.org-article:a31b2588da5a4210aa43a02306851e342021-12-02T16:56:40ZLoss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish10.1038/s41467-018-07054-82041-1723https://doaj.org/article/a31b2588da5a4210aa43a02306851e342018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07054-8https://doaj.org/toc/2041-1723A small percentage of cardiomyocytes (CM) are of neural crest origin but the function of such cells in the adult zebrafish is unclear. Here, the authors identify this CM subpopulation as expressing the Notch ligand jag2b and if deleted in the embryo, cause severe hypertrophic cardiomyopathy in adulthood.Sarah Abdul-WajidBradley L. DemarestH. Joseph YostNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Abdul-Wajid Bradley L. Demarest H. Joseph Yost Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish
description	A small percentage of cardiomyocytes (CM) are of neural crest origin but the function of such cells in the adult zebrafish is unclear. Here, the authors identify this CM subpopulation as expressing the Notch ligand jag2b and if deleted in the embryo, cause severe hypertrophic cardiomyopathy in adulthood.
format	article
author	Sarah Abdul-Wajid Bradley L. Demarest H. Joseph Yost
author_facet	Sarah Abdul-Wajid Bradley L. Demarest H. Joseph Yost
author_sort	Sarah Abdul-Wajid
title	Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish
title_short	Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish
title_full	Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish
title_fullStr	Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish
title_full_unstemmed	Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish
title_sort	loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a31b2588da5a4210aa43a02306851e34
work_keys_str_mv	AT sarahabdulwajid lossofembryonicneuralcrestderivedcardiomyocytescausesadultonsethypertrophiccardiomyopathyinzebrafish AT bradleyldemarest lossofembryonicneuralcrestderivedcardiomyocytescausesadultonsethypertrophiccardiomyopathyinzebrafish AT hjosephyost lossofembryonicneuralcrestderivedcardiomyocytescausesadultonsethypertrophiccardiomyopathyinzebrafish
_version_	1718382758549520384

Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish

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