Principles of age-related changes in the canine and feline brain
In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological charact...
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Sciendo
2014
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oai:doaj.org-article:a31d480c4b8d49fba067dd95a0324b8c2021-11-17T21:27:52ZPrinciples of age-related changes in the canine and feline brain1820-744810.2478/acve-2014-0001https://doaj.org/article/a31d480c4b8d49fba067dd95a0324b8c2014-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0001https://doaj.org/toc/1820-7448In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrelationships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials.Papaioannou NikolaosSciendoarticleaged dogsaged catsamyloidalzheimer diseaseoxidative damageVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 1, Pp 1-9 (2014) |
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| topic |
aged dogs aged cats amyloid alzheimer disease oxidative damage Veterinary medicine SF600-1100 |
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aged dogs aged cats amyloid alzheimer disease oxidative damage Veterinary medicine SF600-1100 Papaioannou Nikolaos Principles of age-related changes in the canine and feline brain |
| description |
In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrelationships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials. |
| format |
article |
| author |
Papaioannou Nikolaos |
| author_facet |
Papaioannou Nikolaos |
| author_sort |
Papaioannou Nikolaos |
| title |
Principles of age-related changes in the canine and feline brain |
| title_short |
Principles of age-related changes in the canine and feline brain |
| title_full |
Principles of age-related changes in the canine and feline brain |
| title_fullStr |
Principles of age-related changes in the canine and feline brain |
| title_full_unstemmed |
Principles of age-related changes in the canine and feline brain |
| title_sort |
principles of age-related changes in the canine and feline brain |
| publisher |
Sciendo |
| publishDate |
2014 |
| url |
https://doaj.org/article/a31d480c4b8d49fba067dd95a0324b8c |
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AT papaioannounikolaos principlesofagerelatedchangesinthecanineandfelinebrain |
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1718425304071929856 |