In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles

Yingqi Li,1,2 Yaoli Tong,1 Ruixia Cao,1 Zhimei Tian,2 Binsheng Yang,2 Pin Yang2 1Department of Chemistry, College of Chemistry and Chemical Engineering, 2Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan...

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Autores principales:	Li Y, Tong Y, Cao R, Tian Z, Yang B, Yang P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a32337ccbbb74f448c437e2152e9c68f
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spelling	oai:doaj.org-article:a32337ccbbb74f448c437e2152e9c68f2021-12-02T02:10:26ZIn vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles1178-2013https://doaj.org/article/a32337ccbbb74f448c437e2152e9c68f2014-02-01T00:00:00Zhttp://www.dovepress.com/in-vivo-enhancement-of-anticancer-therapy-using-bare-or-chemotherapeut-a15917https://doaj.org/toc/1178-2013 Yingqi Li,1,2 Yaoli Tong,1 Ruixia Cao,1 Zhimei Tian,2 Binsheng Yang,2 Pin Yang2 1Department of Chemistry, College of Chemistry and Chemical Engineering, 2Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, People's Republic of China Background: This study investigated the use of nanodiamond particles (NDs) as a promising material for drug delivery in vivo and in vitro. Methods: HepG2 cells (a human hepatic carcinoma cell line) were used to determine the characteristics of a nanodiamond-doxorubicin complex (ND-DOX) when taken up by cells in vitro using laser scanning confocal microscopy and dialysis experiments. We also compared the survival rate and histopathology of tumor-bearing mice after treatment with NDs or ND-DOX in vivo. Results: In vitro investigation showed that ND-DOX has slow and sustained drug release characteristics compared with free doxorubicin. In vivo, the survival rate of tumor-bearing mice treated with ND-DOX was four times greater than that of mice treated with free doxorubicin. Interestingly, the survival rate in mice treated with NDs alone was close to that of mice treated with free doxorubicin. This indicates that treatment with ND-DOX can prolong the lifespan of tumor-bearing mice significantly compared with conventional doxorubicin and that NDs can have this effect as well. Histopathological analysis showed that neither the NDs nor ND-DOX were toxic to the kidney, liver, or spleen in contrast with the well-known toxic effects of free doxorubicin on the kidney and liver. Further, both the bare NDs and ND-DOX could suppress tumor growth effectively. Conclusion: NDs can potentially prolong survival, and ND-DOX may act as a nanodrug with promising chemotherapeutic efficacy and safety.  Keywords: nanodiamond, drug delivery, sustained release, survival rate, cancer, treatmentLi YTong YCao RTian ZYang BYang PDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1065-1082 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li Y Tong Y Cao R Tian Z Yang B Yang P In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles
description	Yingqi Li,1,2 Yaoli Tong,1 Ruixia Cao,1 Zhimei Tian,2 Binsheng Yang,2 Pin Yang2 1Department of Chemistry, College of Chemistry and Chemical Engineering, 2Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, People's Republic of China Background: This study investigated the use of nanodiamond particles (NDs) as a promising material for drug delivery in vivo and in vitro. Methods: HepG2 cells (a human hepatic carcinoma cell line) were used to determine the characteristics of a nanodiamond-doxorubicin complex (ND-DOX) when taken up by cells in vitro using laser scanning confocal microscopy and dialysis experiments. We also compared the survival rate and histopathology of tumor-bearing mice after treatment with NDs or ND-DOX in vivo. Results: In vitro investigation showed that ND-DOX has slow and sustained drug release characteristics compared with free doxorubicin. In vivo, the survival rate of tumor-bearing mice treated with ND-DOX was four times greater than that of mice treated with free doxorubicin. Interestingly, the survival rate in mice treated with NDs alone was close to that of mice treated with free doxorubicin. This indicates that treatment with ND-DOX can prolong the lifespan of tumor-bearing mice significantly compared with conventional doxorubicin and that NDs can have this effect as well. Histopathological analysis showed that neither the NDs nor ND-DOX were toxic to the kidney, liver, or spleen in contrast with the well-known toxic effects of free doxorubicin on the kidney and liver. Further, both the bare NDs and ND-DOX could suppress tumor growth effectively. Conclusion: NDs can potentially prolong survival, and ND-DOX may act as a nanodrug with promising chemotherapeutic efficacy and safety.  Keywords: nanodiamond, drug delivery, sustained release, survival rate, cancer, treatment
format	article
author	Li Y Tong Y Cao R Tian Z Yang B Yang P
author_facet	Li Y Tong Y Cao R Tian Z Yang B Yang P
author_sort	Li Y
title	In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles
title_short	In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles
title_full	In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles
title_fullStr	In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles
title_full_unstemmed	In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles
title_sort	in vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/a32337ccbbb74f448c437e2152e9c68f
work_keys_str_mv	AT liy invivoenhancementofanticancertherapyusingbareorchemotherapeuticdrugbearingnanodiamondparticles AT tongy invivoenhancementofanticancertherapyusingbareorchemotherapeuticdrugbearingnanodiamondparticles AT caor invivoenhancementofanticancertherapyusingbareorchemotherapeuticdrugbearingnanodiamondparticles AT tianz invivoenhancementofanticancertherapyusingbareorchemotherapeuticdrugbearingnanodiamondparticles AT yangb invivoenhancementofanticancertherapyusingbareorchemotherapeuticdrugbearingnanodiamondparticles AT yangp invivoenhancementofanticancertherapyusingbareorchemotherapeuticdrugbearingnanodiamondparticles
_version_	1718402666114056192

In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles

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