EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY

Objective: To ascertain the effectiveness of immunosuppressants along with ACEI and /or ARBS in proteinuria in patients with solitary kidney post nephrectomy. Study Design: Prospective quasi-experimental study. Place and Duration of Study: Combined Military Hospital Peshawar and Multan, from 2010...

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Autores principales:	Nadeem Azam, Fuad Ahmad Siddiqi, Koukab Javed, Batool Butt
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	immunosuppressants post nephrectomy proteinuria Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a3241e8e34414ed4b156471bccc7a9d5
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spelling	oai:doaj.org-article:a3241e8e34414ed4b156471bccc7a9d52021-12-02T03:12:34ZEFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY0030-96482411-8842https://doaj.org/article/a3241e8e34414ed4b156471bccc7a9d52018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2290/1986https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To ascertain the effectiveness of immunosuppressants along with ACEI and /or ARBS in proteinuria in patients with solitary kidney post nephrectomy. Study Design: Prospective quasi-experimental study. Place and Duration of Study: Combined Military Hospital Peshawar and Multan, from 2010 to 2016. Subjects and Methods: The sample population comprised of 07 cases of post nephrectomy solitary kidney developing proteinuria from 2010-2016 reporting to hospitals. Patients were given initially ACEI and/or ARBS to lower proteinuria for three months. They were followed up to see for complete or partial remission. Deltacortil 1mg/kg max 60mg/day along with ACEI and /or ARBS was added to patients who didn’t go into remission. Results: Out of 7 patients, 3 (42.9%) were males and 4 (57.1%) were female patients. Addition of deltacortil 1mg/kg max 60mg/day along with ACEI and /or ARBS reduced proteinuria to less than 1 gram in 3 patients (2 males and 1 female) and less than 300mg in 4 patients (1 male and 3 females).There was a reduction in the mean 24hrs urinary protein excretion as a whole from the baseline 2.33 ± 0.84 g/24 hrs to 0.48 ± 0.33 g/24 hrs. Remission was achieved on the average in three months and maintenance on tapering doses for 12 months. Cyclosporine was used in three cases who relapsed on tapering steroids and remission was achieved with 5-10mg steroids and 100-200mg of cyclosporine. Conclusion: Non respondent patients with solitary kidney developing proteinuria being treated with ACEI and /or ARBS had good chance to lower their proteinuria with steroids. Relapses even with steroids responded to cyclosporine.Nadeem AzamFuad Ahmad SiddiqiKoukab JavedBatool ButtArmy Medical College Rawalpindiarticleimmunosuppressantspost nephrectomyproteinuriaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1194-1198 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunosuppressants post nephrectomy proteinuria Medicine R Medicine (General) R5-920
spellingShingle	immunosuppressants post nephrectomy proteinuria Medicine R Medicine (General) R5-920 Nadeem Azam Fuad Ahmad Siddiqi Koukab Javed Batool Butt EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY
description	Objective: To ascertain the effectiveness of immunosuppressants along with ACEI and /or ARBS in proteinuria in patients with solitary kidney post nephrectomy. Study Design: Prospective quasi-experimental study. Place and Duration of Study: Combined Military Hospital Peshawar and Multan, from 2010 to 2016. Subjects and Methods: The sample population comprised of 07 cases of post nephrectomy solitary kidney developing proteinuria from 2010-2016 reporting to hospitals. Patients were given initially ACEI and/or ARBS to lower proteinuria for three months. They were followed up to see for complete or partial remission. Deltacortil 1mg/kg max 60mg/day along with ACEI and /or ARBS was added to patients who didn’t go into remission. Results: Out of 7 patients, 3 (42.9%) were males and 4 (57.1%) were female patients. Addition of deltacortil 1mg/kg max 60mg/day along with ACEI and /or ARBS reduced proteinuria to less than 1 gram in 3 patients (2 males and 1 female) and less than 300mg in 4 patients (1 male and 3 females).There was a reduction in the mean 24hrs urinary protein excretion as a whole from the baseline 2.33 ± 0.84 g/24 hrs to 0.48 ± 0.33 g/24 hrs. Remission was achieved on the average in three months and maintenance on tapering doses for 12 months. Cyclosporine was used in three cases who relapsed on tapering steroids and remission was achieved with 5-10mg steroids and 100-200mg of cyclosporine. Conclusion: Non respondent patients with solitary kidney developing proteinuria being treated with ACEI and /or ARBS had good chance to lower their proteinuria with steroids. Relapses even with steroids responded to cyclosporine.
format	article
author	Nadeem Azam Fuad Ahmad Siddiqi Koukab Javed Batool Butt
author_facet	Nadeem Azam Fuad Ahmad Siddiqi Koukab Javed Batool Butt
author_sort	Nadeem Azam
title	EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY
title_short	EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY
title_full	EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY
title_fullStr	EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY
title_full_unstemmed	EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY
title_sort	effectiveness of immunosuppressants along with acei/arbs in treating proteinuria in patients with solitary kidney post nephrectomy
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/a3241e8e34414ed4b156471bccc7a9d5
work_keys_str_mv	AT nadeemazam effectivenessofimmunosuppressantsalongwithaceiarbsintreatingproteinuriainpatientswithsolitarykidneypostnephrectomy AT fuadahmadsiddiqi effectivenessofimmunosuppressantsalongwithaceiarbsintreatingproteinuriainpatientswithsolitarykidneypostnephrectomy AT koukabjaved effectivenessofimmunosuppressantsalongwithaceiarbsintreatingproteinuriainpatientswithsolitarykidneypostnephrectomy AT batoolbutt effectivenessofimmunosuppressantsalongwithaceiarbsintreatingproteinuriainpatientswithsolitarykidneypostnephrectomy
_version_	1718401874960318464

EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY

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