Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that are rapidly excreted by the kidney and with high a...

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Autores principales:	Edmund J. Keliher, Yu-Xiang Ye, Gregory R. Wojtkiewicz, Aaron D. Aguirre, Benoit Tricot, Max L. Senders, Hannah Groenen, Francois Fay, Carlos Perez-Medina, Claudia Calcagno, Giuseppe Carlucci, Thomas Reiner, Yuan Sun, Gabriel Courties, Yoshiko Iwamoto, Hye-Yeong Kim, Cuihua Wang, John W. Chen, Filip K. Swirski, Hsiao-Ying Wey, Jacob Hooker, Zahi A. Fayad, Willem J. M. Mulder, Ralph Weissleder, Matthias Nahrendorf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a325edd59ddf4dab8474aa0b334a7eea
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spelling	oai:doaj.org-article:a325edd59ddf4dab8474aa0b334a7eea2021-12-02T14:42:37ZPolyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease10.1038/ncomms140642041-1723https://doaj.org/article/a325edd59ddf4dab8474aa0b334a7eea2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14064https://doaj.org/toc/2041-1723In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that are rapidly excreted by the kidney and with high affinity for macrophages in atherosclerotic plaques.Edmund J. KeliherYu-Xiang YeGregory R. WojtkiewiczAaron D. AguirreBenoit TricotMax L. SendersHannah GroenenFrancois FayCarlos Perez-MedinaClaudia CalcagnoGiuseppe CarlucciThomas ReinerYuan SunGabriel CourtiesYoshiko IwamotoHye-Yeong KimCuihua WangJohn W. ChenFilip K. SwirskiHsiao-Ying WeyJacob HookerZahi A. FayadWillem J. M. MulderRalph WeisslederMatthias NahrendorfNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edmund J. Keliher Yu-Xiang Ye Gregory R. Wojtkiewicz Aaron D. Aguirre Benoit Tricot Max L. Senders Hannah Groenen Francois Fay Carlos Perez-Medina Claudia Calcagno Giuseppe Carlucci Thomas Reiner Yuan Sun Gabriel Courties Yoshiko Iwamoto Hye-Yeong Kim Cuihua Wang John W. Chen Filip K. Swirski Hsiao-Ying Wey Jacob Hooker Zahi A. Fayad Willem J. M. Mulder Ralph Weissleder Matthias Nahrendorf Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
description	In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that are rapidly excreted by the kidney and with high affinity for macrophages in atherosclerotic plaques.
format	article
author	Edmund J. Keliher Yu-Xiang Ye Gregory R. Wojtkiewicz Aaron D. Aguirre Benoit Tricot Max L. Senders Hannah Groenen Francois Fay Carlos Perez-Medina Claudia Calcagno Giuseppe Carlucci Thomas Reiner Yuan Sun Gabriel Courties Yoshiko Iwamoto Hye-Yeong Kim Cuihua Wang John W. Chen Filip K. Swirski Hsiao-Ying Wey Jacob Hooker Zahi A. Fayad Willem J. M. Mulder Ralph Weissleder Matthias Nahrendorf
author_facet	Edmund J. Keliher Yu-Xiang Ye Gregory R. Wojtkiewicz Aaron D. Aguirre Benoit Tricot Max L. Senders Hannah Groenen Francois Fay Carlos Perez-Medina Claudia Calcagno Giuseppe Carlucci Thomas Reiner Yuan Sun Gabriel Courties Yoshiko Iwamoto Hye-Yeong Kim Cuihua Wang John W. Chen Filip K. Swirski Hsiao-Ying Wey Jacob Hooker Zahi A. Fayad Willem J. M. Mulder Ralph Weissleder Matthias Nahrendorf
author_sort	Edmund J. Keliher
title	Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
title_short	Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
title_full	Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
title_fullStr	Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
title_full_unstemmed	Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
title_sort	polyglucose nanoparticles with renal elimination and macrophage avidity facilitate pet imaging in ischaemic heart disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a325edd59ddf4dab8474aa0b334a7eea
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Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

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