AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus.

The MUC2 mucin is the major constituent of the two mucus layers in colon. Mice lacking the disulfide isomerase-like protein Agr2 have been shown to be more susceptible to colon inflammation. The Agr2(-/-) mice have less filled goblet cells and were now shown to have a poorly developed inner colon mu...

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Autores principales: Joakim H Bergström, Katarina A Berg, Ana M Rodríguez-Piñeiro, Bärbel Stecher, Malin E V Johansson, Gunnar C Hansson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/a32a76d0146a45258a5f10e12b382c2e
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