A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults

A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults

Yong-hua Cui,1 Yi Zheng1,2 1Department of Pediatrics, Beijing An’ding Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Institutes of Brain Disorders, Beijing, People’s Republic of China Objective: The aim of the study was to investig...

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Autores principales: Cui YH, Zheng Y
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
St. John’s wort
selective serotonin reuptake inhibitors
depression
meta-analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/a32ecee529604081b14e9bcdd0754a43
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spelling oai:doaj.org-article:a32ecee529604081b14e9bcdd0754a432021-12-02T00:25:24ZA meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults1178-2021https://doaj.org/article/a32ecee529604081b14e9bcdd0754a432016-07-01T00:00:00Zhttps://www.dovepress.com/a-meta-analysis-on-the-efficacy-and-safety-of-st-john39s-wort-extract--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yong-hua Cui,1 Yi Zheng1,2 1Department of Pediatrics, Beijing An’ding Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Institutes of Brain Disorders, Beijing, People’s Republic of China Objective: The aim of the study was to investigate the efficacy and safety of St John’s wort extract and selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression.Methods: Databases were searched for studies comparing efficacy and/or safety of St John’s wort extract with SSRIs in depression from 1966 to April 2015. Stata software was used for statistical analysis.Results: Twenty-seven studies met the study entry criteria. A total of 3,126 patients with depression were included. St John’s wort extract did not differ from SSRIs in clinical response, remission, and mean reduction in Hamilton Rating Scale for Depression score. St John’s wort extract had a significantly lower rate of adverse events compared to SSRIs (summary relative risk: 0.77; 95% confidence interval: 0.70, 0.84, P=0.00) and had fewer withdrawals due to adverse events. St John’s wort extract had superior safety in the management of patients with depression.Conclusion: Both St John’s wort extract and SSRIs are effective in treating mild-to-moderate depression. St John’s wort extract is safer than SSRIs. Keywords: St John’s wort, selective serotonin reuptake inhibitors, depression, meta-analysis Cui YHZheng YDove Medical PressarticleSt. John’s wortselective serotonin reuptake inhibitorsdepressionmeta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1715-1723 (2016)
institution DOAJ
collection DOAJ
language EN
topic St. John’s wort
selective serotonin reuptake inhibitors
depression
meta-analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle St. John’s wort
selective serotonin reuptake inhibitors
depression
meta-analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Cui YH
Zheng Y
A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults
description Yong-hua Cui,1 Yi Zheng1,2 1Department of Pediatrics, Beijing An’ding Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Institutes of Brain Disorders, Beijing, People’s Republic of China Objective: The aim of the study was to investigate the efficacy and safety of St John’s wort extract and selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression.Methods: Databases were searched for studies comparing efficacy and/or safety of St John’s wort extract with SSRIs in depression from 1966 to April 2015. Stata software was used for statistical analysis.Results: Twenty-seven studies met the study entry criteria. A total of 3,126 patients with depression were included. St John’s wort extract did not differ from SSRIs in clinical response, remission, and mean reduction in Hamilton Rating Scale for Depression score. St John’s wort extract had a significantly lower rate of adverse events compared to SSRIs (summary relative risk: 0.77; 95% confidence interval: 0.70, 0.84, P=0.00) and had fewer withdrawals due to adverse events. St John’s wort extract had superior safety in the management of patients with depression.Conclusion: Both St John’s wort extract and SSRIs are effective in treating mild-to-moderate depression. St John’s wort extract is safer than SSRIs. Keywords: St John’s wort, selective serotonin reuptake inhibitors, depression, meta-analysis 
format article
author Cui YH
Zheng Y
author_facet Cui YH
Zheng Y
author_sort Cui YH
title A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults
title_short A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults
title_full A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults
title_fullStr A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults
title_full_unstemmed A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults
title_sort meta-analysis on the efficacy and safety of st john's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/a32ecee529604081b14e9bcdd0754a43
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