Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.

<h4>Objective</h4>We aimed to investigate how lean body mass is related to circulating Interleukin 18 (IL-18) and its association with metabolic syndrome (MetS) among apparently healthy Chinese.<h4>Methods</h4>A population-based sample of 1059 Chinese men and women aged 35-54...

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Autores principales:	Liang Sun, Frank B Hu, Zhijie Yu, Huaixing Li, Huaiyu Liu, Xiangdong Wang, Danxia Yu, Hongyu Wu, Geng Zhang, Geng Zong, Yong Liu, Xu Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3303482bbc24bea993e2d5b57cadcb1
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spelling	oai:doaj.org-article:a3303482bbc24bea993e2d5b57cadcb12021-11-18T06:57:11ZLean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.1932-620310.1371/journal.pone.0018104https://doaj.org/article/a3303482bbc24bea993e2d5b57cadcb12011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21437204/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>We aimed to investigate how lean body mass is related to circulating Interleukin 18 (IL-18) and its association with metabolic syndrome (MetS) among apparently healthy Chinese.<h4>Methods</h4>A population-based sample of 1059 Chinese men and women aged 35-54 years was used to measure plasma IL-18, glucose, insulin, lipid profile, inflammatory markers and high-molecular-weight (HMW)-adiponectin. Fat mass index (FMI) and lean mass index (LMI) were measured by dual-energy X-ray absorptiometry. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans.<h4>Results</h4>Circulating IL-18 was positively correlated with LMI after adjustment for FMI (correlation coefficient = 0.11, P<0.001). The association with the MetS (odds ratio 3.43, 95% confidence interval 2.01-5.85) was substantially higher in the highest than the lowest quartile of IL-18 after multiple adjustments including body mass index. In the stratified multivariable regression analyses, the positive association between IL-18 and MetS was independent of tertiles of FMI, inflammatory markers and HMW-adiponectin, but significantly interacted with tertile of LMI (P for interaction = 0.010).<h4>Conclusion</h4>Elevated plasma IL-18 was associated with higher MetS prevalence in apparently healthy Chinese, independent of traditional risk factors, FMI, inflammatory markers and HMW-adiponectin. More studies are needed to clarify the role of lean mass in IL-18 secretion and its associated cardio-metabolic disorders.Liang SunFrank B HuZhijie YuHuaixing LiHuaiyu LiuXiangdong WangDanxia YuHongyu WuGeng ZhangGeng ZongYong LiuXu LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e18104 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Sun Frank B Hu Zhijie Yu Huaixing Li Huaiyu Liu Xiangdong Wang Danxia Yu Hongyu Wu Geng Zhang Geng Zong Yong Liu Xu Lin Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.
description	<h4>Objective</h4>We aimed to investigate how lean body mass is related to circulating Interleukin 18 (IL-18) and its association with metabolic syndrome (MetS) among apparently healthy Chinese.<h4>Methods</h4>A population-based sample of 1059 Chinese men and women aged 35-54 years was used to measure plasma IL-18, glucose, insulin, lipid profile, inflammatory markers and high-molecular-weight (HMW)-adiponectin. Fat mass index (FMI) and lean mass index (LMI) were measured by dual-energy X-ray absorptiometry. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans.<h4>Results</h4>Circulating IL-18 was positively correlated with LMI after adjustment for FMI (correlation coefficient = 0.11, P<0.001). The association with the MetS (odds ratio 3.43, 95% confidence interval 2.01-5.85) was substantially higher in the highest than the lowest quartile of IL-18 after multiple adjustments including body mass index. In the stratified multivariable regression analyses, the positive association between IL-18 and MetS was independent of tertiles of FMI, inflammatory markers and HMW-adiponectin, but significantly interacted with tertile of LMI (P for interaction = 0.010).<h4>Conclusion</h4>Elevated plasma IL-18 was associated with higher MetS prevalence in apparently healthy Chinese, independent of traditional risk factors, FMI, inflammatory markers and HMW-adiponectin. More studies are needed to clarify the role of lean mass in IL-18 secretion and its associated cardio-metabolic disorders.
format	article
author	Liang Sun Frank B Hu Zhijie Yu Huaixing Li Huaiyu Liu Xiangdong Wang Danxia Yu Hongyu Wu Geng Zhang Geng Zong Yong Liu Xu Lin
author_facet	Liang Sun Frank B Hu Zhijie Yu Huaixing Li Huaiyu Liu Xiangdong Wang Danxia Yu Hongyu Wu Geng Zhang Geng Zong Yong Liu Xu Lin
author_sort	Liang Sun
title	Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.
title_short	Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.
title_full	Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.
title_fullStr	Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.
title_full_unstemmed	Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.
title_sort	lean body mass, interleukin 18, and metabolic syndrome in apparently healthy chinese.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a3303482bbc24bea993e2d5b57cadcb1
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Lean body mass, interleukin 18, and metabolic syndrome in apparently healthy Chinese.

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