Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and chaperone activity.

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Autores principales:	Levi J. McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Shanshan Li, Celestine J. Thomas, Tzanko I. Doukov, Sarah Triest, Alexandre Wohlkonig, Gregory G. Tall, Jan Steyaert, Wah Chiu, Stephen R. Sprang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3332f800ecb43968d52458b851393bf
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spelling	oai:doaj.org-article:a3332f800ecb43968d52458b851393bf2021-12-02T14:40:54ZStructure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi110.1038/s41467-020-14943-42041-1723https://doaj.org/article/a3332f800ecb43968d52458b851393bf2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14943-4https://doaj.org/toc/2041-1723Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and chaperone activity.Levi J. McClellandKaiming ZhangTung-Chung MouJake JohnstonCindee Yates-HansenShanshan LiCelestine J. ThomasTzanko I. DoukovSarah TriestAlexandre WohlkonigGregory G. TallJan SteyaertWah ChiuStephen R. SprangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Levi J. McClelland Kaiming Zhang Tung-Chung Mou Jake Johnston Cindee Yates-Hansen Shanshan Li Celestine J. Thomas Tzanko I. Doukov Sarah Triest Alexandre Wohlkonig Gregory G. Tall Jan Steyaert Wah Chiu Stephen R. Sprang Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
description	Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and chaperone activity.
format	article
author	Levi J. McClelland Kaiming Zhang Tung-Chung Mou Jake Johnston Cindee Yates-Hansen Shanshan Li Celestine J. Thomas Tzanko I. Doukov Sarah Triest Alexandre Wohlkonig Gregory G. Tall Jan Steyaert Wah Chiu Stephen R. Sprang
author_facet	Levi J. McClelland Kaiming Zhang Tung-Chung Mou Jake Johnston Cindee Yates-Hansen Shanshan Li Celestine J. Thomas Tzanko I. Doukov Sarah Triest Alexandre Wohlkonig Gregory G. Tall Jan Steyaert Wah Chiu Stephen R. Sprang
author_sort	Levi J. McClelland
title	Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
title_short	Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
title_full	Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
title_fullStr	Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
title_full_unstemmed	Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
title_sort	structure of the g protein chaperone and guanine nucleotide exchange factor ric-8a bound to gαi1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a3332f800ecb43968d52458b851393bf
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Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

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