Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and chaperone activity.

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Detalles Bibliográficos
Autores principales: Levi J. McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Shanshan Li, Celestine J. Thomas, Tzanko I. Doukov, Sarah Triest, Alexandre Wohlkonig, Gregory G. Tall, Jan Steyaert, Wah Chiu, Stephen R. Sprang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/a3332f800ecb43968d52458b851393bf
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https://doaj.org/article/a3332f800ecb43968d52458b851393bf

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