Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study

Gong Feng,1 Wu-Bin Shu,2 A-Bing Li2 1School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, People’s Republic of China; 2Department of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, 315100, Zhejiang, People’s Republic of ChinaCorrespondence: A-Bing LiDepartment of Orthopedics, Ningbo...

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Autores principales:	Feng G, Shu WB, Li AB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	solitary bone plasmacytoma cancer risk factors seer nomogram Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a3395dd0da354bcca586eb0b20793f1f
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spelling	oai:doaj.org-article:a3395dd0da354bcca586eb0b20793f1f2021-11-23T18:43:01ZPrognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study1178-7074https://doaj.org/article/a3395dd0da354bcca586eb0b20793f1f2021-11-01T00:00:00Zhttps://www.dovepress.com/prognostic-nomogram-for-predicting-overall-survival-of-solitary-bone-p-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Gong Feng,1 Wu-Bin Shu,2 A-Bing Li2 1School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, People’s Republic of China; 2Department of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, 315100, Zhejiang, People’s Republic of ChinaCorrespondence: A-Bing LiDepartment of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang, 315100, People’s Republic of ChinaTel +86-15088557621Email bing19890807@hotmail.comBackground: The aim of the study was to develop a nomogram to predict the overall survival (OS) of patients with solitary plasmacytoma of bone (SBP).Materials and Methods: Patients diagnosed with SBP between 1993 and 2012 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. All eligible patients were randomly allocated to the training sets and the validation sets. The nomogram was developed with the training set and validated with the validation set using the concordance index (C-index), calibration plots, and decision curve analyses (DCA).Results: Age, marital status, tumor grade, treatment were independent prognostic indicators for OS (P< 0.05) and were integrated to construct the nomogram. C-indexes for OS prediction in the training and validation sets were 0.78 and 0.73, respectively. The calibration plots demonstrated good consistency between the predicted and actual survival. DCA demonstrated that the new model has great benefits. In the total cohort, the median OS of patients in the low- and high-risk groups were 12.17 (95% CI 11.92– 12.42) and 3.92 (95% CI 2.83– 5.01) years, respectively.Conclusion: The nomogram showed excellent applicability and accuracy, which could be a reliable tool for predicting OS in SBP patients.Keywords: solitary bone plasmacytoma, cancer risk factors, SEER, nomogramFeng GShu WBLi ABDove Medical Pressarticlesolitary bone plasmacytomacancer risk factorsseernomogramMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8621-8630 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	solitary bone plasmacytoma cancer risk factors seer nomogram Medicine (General) R5-920
spellingShingle	solitary bone plasmacytoma cancer risk factors seer nomogram Medicine (General) R5-920 Feng G Shu WB Li AB Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study
description	Gong Feng,1 Wu-Bin Shu,2 A-Bing Li2 1School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, People’s Republic of China; 2Department of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, 315100, Zhejiang, People’s Republic of ChinaCorrespondence: A-Bing LiDepartment of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang, 315100, People’s Republic of ChinaTel +86-15088557621Email bing19890807@hotmail.comBackground: The aim of the study was to develop a nomogram to predict the overall survival (OS) of patients with solitary plasmacytoma of bone (SBP).Materials and Methods: Patients diagnosed with SBP between 1993 and 2012 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. All eligible patients were randomly allocated to the training sets and the validation sets. The nomogram was developed with the training set and validated with the validation set using the concordance index (C-index), calibration plots, and decision curve analyses (DCA).Results: Age, marital status, tumor grade, treatment were independent prognostic indicators for OS (P< 0.05) and were integrated to construct the nomogram. C-indexes for OS prediction in the training and validation sets were 0.78 and 0.73, respectively. The calibration plots demonstrated good consistency between the predicted and actual survival. DCA demonstrated that the new model has great benefits. In the total cohort, the median OS of patients in the low- and high-risk groups were 12.17 (95% CI 11.92– 12.42) and 3.92 (95% CI 2.83– 5.01) years, respectively.Conclusion: The nomogram showed excellent applicability and accuracy, which could be a reliable tool for predicting OS in SBP patients.Keywords: solitary bone plasmacytoma, cancer risk factors, SEER, nomogram
format	article
author	Feng G Shu WB Li AB
author_facet	Feng G Shu WB Li AB
author_sort	Feng G
title	Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study
title_short	Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study
title_full	Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study
title_fullStr	Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study
title_full_unstemmed	Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study
title_sort	prognostic nomogram for predicting overall survival of solitary bone plasmacytoma patients: a large population-based study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a3395dd0da354bcca586eb0b20793f1f
work_keys_str_mv	AT fengg prognosticnomogramforpredictingoverallsurvivalofsolitaryboneplasmacytomapatientsalargepopulationbasedstudy AT shuwb prognosticnomogramforpredictingoverallsurvivalofsolitaryboneplasmacytomapatientsalargepopulationbasedstudy AT liab prognosticnomogramforpredictingoverallsurvivalofsolitaryboneplasmacytomapatientsalargepopulationbasedstudy
_version_	1718416170892132352

Prognostic Nomogram for Predicting Overall Survival of Solitary Bone Plasmacytoma Patients: A Large Population-Based Study

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