Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes

Rizwana Parveen1, Prem Kapur2, Shubhashree Venkatesh3, Nidhi Bharal Agarwal3 1Department of Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India; 2Hamdard Institute of Medical Sciences and Research, HAH Centenary Hospital, Jamia Hamdard, Ne...

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Autores principales:	Parveen R, Kapur P, Venkatesh S, Agarwal NB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Hypovitaminosis D Mini-mental state examination vitamin-D insufficiency cognitive dysfunction Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/a33b83e6d72241c28843fb3636cd7403
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spelling	oai:doaj.org-article:a33b83e6d72241c28843fb3636cd74032021-12-02T07:53:50ZAttenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes1178-7007https://doaj.org/article/a33b83e6d72241c28843fb3636cd74032019-09-01T00:00:00Zhttps://www.dovepress.com/attenuated-serum-25-hydroxyvitamin-d-and-vitamin-d-binding-protein-ass-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Rizwana Parveen1, Prem Kapur2, Shubhashree Venkatesh3, Nidhi Bharal Agarwal3 1Department of Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India; 2Hamdard Institute of Medical Sciences and Research, HAH Centenary Hospital, Jamia Hamdard, New Delhi 110062, India; 3Centre for Translational and Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi 110062, IndiaCorrespondence: Nidhi Bharal AgarwalCentre for Translational and Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi 110062, IndiaTel +91 981 833 4770Email nidhi.bharal@gmail.comPurpose: Clinical studies suggest that 25-hydroxyvitamin D (25[OH]D) deficiency plays a pivotal role in both type 2 diabetes mellitus (T2DM) and cognitive impairment. However, it is unclear if 25(OH)D deficiency could be a possible cause of cognitive impairment in T2DM. Vitamin-D binding protein (VDBP) acts as a major 25(OH)D transporter. Preclinical study has demonstrated improvement in cognitive function by VDBP via inhibiting synaptic degeneration. The aim of the study was to assess the association between serum 25(OH)D, VDBP and cognitive impairment in T2DM patients.Patients and methods: In this case-control study, cognitive function was assessed using the Mini-Mental State Examination (MMSE) and serum 25(OH)D and VDBP levels were estimated using ELISA kits.Results: A total of 88 subjects were included in the study. T2DM patients had lower serum 25(OH)D (p=0.02), VDBP levels (p=0.04) and MMSE scores (p<0.0001) than controls. T2DM patients had higher prevalence of 25(OH)D deficiency and insufficiency, aOR 0.322 (0.128–0.809), p=0.016 and cognitive impairment, aOR 4.405 (1.617–12.002); p=0.004. Cognitive impairment was associated with serum 25(OH)D, aOR 0.131 (0.027–0.638); p=0.014 and VDBP, aOR 1.008 (1.001–1.015), p=0.029. A general linear model showed a significant association of MMSE with serum 25(OH)D (p=0.022).Conclusion: Serum 25(OH)D deficiency and cognitive impairment was higher in T2DM patients. Routine assessment of cognitive function is suggested to prevent further behavioral complications. The association of VDBP and cognitive impairment in T2DM needs further exploration.Keywords: hypovitaminosis D, Mini-Mental State Examination, vitamin-D insufficiency, cognitive dysfunctionParveen RKapur PVenkatesh SAgarwal NBDove Medical PressarticleHypovitaminosis DMini-mental state examinationvitamin-D insufficiencycognitive dysfunctionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1763-1772 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypovitaminosis D Mini-mental state examination vitamin-D insufficiency cognitive dysfunction Specialties of internal medicine RC581-951
spellingShingle	Hypovitaminosis D Mini-mental state examination vitamin-D insufficiency cognitive dysfunction Specialties of internal medicine RC581-951 Parveen R Kapur P Venkatesh S Agarwal NB Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes
description	Rizwana Parveen1, Prem Kapur2, Shubhashree Venkatesh3, Nidhi Bharal Agarwal3 1Department of Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India; 2Hamdard Institute of Medical Sciences and Research, HAH Centenary Hospital, Jamia Hamdard, New Delhi 110062, India; 3Centre for Translational and Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi 110062, IndiaCorrespondence: Nidhi Bharal AgarwalCentre for Translational and Clinical Research, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi 110062, IndiaTel +91 981 833 4770Email nidhi.bharal@gmail.comPurpose: Clinical studies suggest that 25-hydroxyvitamin D (25[OH]D) deficiency plays a pivotal role in both type 2 diabetes mellitus (T2DM) and cognitive impairment. However, it is unclear if 25(OH)D deficiency could be a possible cause of cognitive impairment in T2DM. Vitamin-D binding protein (VDBP) acts as a major 25(OH)D transporter. Preclinical study has demonstrated improvement in cognitive function by VDBP via inhibiting synaptic degeneration. The aim of the study was to assess the association between serum 25(OH)D, VDBP and cognitive impairment in T2DM patients.Patients and methods: In this case-control study, cognitive function was assessed using the Mini-Mental State Examination (MMSE) and serum 25(OH)D and VDBP levels were estimated using ELISA kits.Results: A total of 88 subjects were included in the study. T2DM patients had lower serum 25(OH)D (p=0.02), VDBP levels (p=0.04) and MMSE scores (p<0.0001) than controls. T2DM patients had higher prevalence of 25(OH)D deficiency and insufficiency, aOR 0.322 (0.128–0.809), p=0.016 and cognitive impairment, aOR 4.405 (1.617–12.002); p=0.004. Cognitive impairment was associated with serum 25(OH)D, aOR 0.131 (0.027–0.638); p=0.014 and VDBP, aOR 1.008 (1.001–1.015), p=0.029. A general linear model showed a significant association of MMSE with serum 25(OH)D (p=0.022).Conclusion: Serum 25(OH)D deficiency and cognitive impairment was higher in T2DM patients. Routine assessment of cognitive function is suggested to prevent further behavioral complications. The association of VDBP and cognitive impairment in T2DM needs further exploration.Keywords: hypovitaminosis D, Mini-Mental State Examination, vitamin-D insufficiency, cognitive dysfunction
format	article
author	Parveen R Kapur P Venkatesh S Agarwal NB
author_facet	Parveen R Kapur P Venkatesh S Agarwal NB
author_sort	Parveen R
title	Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes
title_short	Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes
title_full	Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes
title_fullStr	Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes
title_full_unstemmed	Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes
title_sort	attenuated serum 25-hydroxyvitamin d and vitamin d binding protein associated with cognitive impairment in patients with type 2 diabetes
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a33b83e6d72241c28843fb3636cd7403
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Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes

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