Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.

Moderate exercise training improves energetic metabolism, tissue perfusion and induces cardiac and skeletal muscle remodeling. Sildenafil, a potent phosphodiesterase-5 inhibitor used to treat erectile dysfunction, reduces infarct size and increases tissue oxygenation in experimental models of cardio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Barbara Rinaldi, Maria Donniacuo, Loredana Sodano, Giulia Gritti, Simona Signoriello, Elisabetta Parretta, Liberato Berrino, Konrad Urbanek, Annalisa Capuano, Francesco Rossi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a33ba69c381749b48404ab2ebf2bb748
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a33ba69c381749b48404ab2ebf2bb748
record_format	dspace
spelling	oai:doaj.org-article:a33ba69c381749b48404ab2ebf2bb7482021-11-18T09:02:21ZEffects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.1932-620310.1371/journal.pone.0069954https://doaj.org/article/a33ba69c381749b48404ab2ebf2bb7482013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23922868/?tool=EBIhttps://doaj.org/toc/1932-6203Moderate exercise training improves energetic metabolism, tissue perfusion and induces cardiac and skeletal muscle remodeling. Sildenafil, a potent phosphodiesterase-5 inhibitor used to treat erectile dysfunction, reduces infarct size and increases tissue oxygenation in experimental models of cardiovascular disease. We have evaluated the effects of prolonged moderate exercise training and a repeat administration of sildenafil on the rat gastrocnemius and cardiac muscles. Animals were divided into two groups: sedentary and trained. Each group was subdivided into animals treated with vehicle or with two doses of sildenafil (10 or 15 mg/kg/day) during the last week of training. Physical exercise did not induce cardiac hypertrophy, whereas it increased mRNA levels of the PGC-1α, HIF-1α and VEGF genes, which are involved in mitochondrial biogenesis and angiogenesis, and reduced mRNA levels of FoxO3a, MuRF-1 and Atrogin-1. Sildenafil dose-dependently promoted both angiogenesis, as shown by increased capillary density, and muscle atrophy, as shown by muscle fibre size. These effects were more pronounced in trained animals. Our data confirm the beneficial effects of a moderate and prolonged training on cardiovascular and skeletal systems and document the positive and negative effects of sildenafil on these tissues at doses higher than those used in clinical practice. This report may impact on the use of sildenafil as a substance able to influence sports performance.Barbara RinaldiMaria DonniacuoLoredana SodanoGiulia GrittiSimona SignorielloElisabetta ParrettaLiberato BerrinoKonrad UrbanekAnnalisa CapuanoFrancesco RossiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69954 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barbara Rinaldi Maria Donniacuo Loredana Sodano Giulia Gritti Simona Signoriello Elisabetta Parretta Liberato Berrino Konrad Urbanek Annalisa Capuano Francesco Rossi Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.
description	Moderate exercise training improves energetic metabolism, tissue perfusion and induces cardiac and skeletal muscle remodeling. Sildenafil, a potent phosphodiesterase-5 inhibitor used to treat erectile dysfunction, reduces infarct size and increases tissue oxygenation in experimental models of cardiovascular disease. We have evaluated the effects of prolonged moderate exercise training and a repeat administration of sildenafil on the rat gastrocnemius and cardiac muscles. Animals were divided into two groups: sedentary and trained. Each group was subdivided into animals treated with vehicle or with two doses of sildenafil (10 or 15 mg/kg/day) during the last week of training. Physical exercise did not induce cardiac hypertrophy, whereas it increased mRNA levels of the PGC-1α, HIF-1α and VEGF genes, which are involved in mitochondrial biogenesis and angiogenesis, and reduced mRNA levels of FoxO3a, MuRF-1 and Atrogin-1. Sildenafil dose-dependently promoted both angiogenesis, as shown by increased capillary density, and muscle atrophy, as shown by muscle fibre size. These effects were more pronounced in trained animals. Our data confirm the beneficial effects of a moderate and prolonged training on cardiovascular and skeletal systems and document the positive and negative effects of sildenafil on these tissues at doses higher than those used in clinical practice. This report may impact on the use of sildenafil as a substance able to influence sports performance.
format	article
author	Barbara Rinaldi Maria Donniacuo Loredana Sodano Giulia Gritti Simona Signoriello Elisabetta Parretta Liberato Berrino Konrad Urbanek Annalisa Capuano Francesco Rossi
author_facet	Barbara Rinaldi Maria Donniacuo Loredana Sodano Giulia Gritti Simona Signoriello Elisabetta Parretta Liberato Berrino Konrad Urbanek Annalisa Capuano Francesco Rossi
author_sort	Barbara Rinaldi
title	Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.
title_short	Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.
title_full	Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.
title_fullStr	Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.
title_full_unstemmed	Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.
title_sort	effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a33ba69c381749b48404ab2ebf2bb748
work_keys_str_mv	AT barbararinaldi effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT mariadonniacuo effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT loredanasodano effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT giuliagritti effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT simonasignoriello effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT elisabettaparretta effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT liberatoberrino effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT konradurbanek effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT annalisacapuano effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining AT francescorossi effectsofsildenafilonthegastrocnemiusandcardiacmusclesofratsinamodelofprolongedmoderateexercisetraining
_version_	1718421040277749760

Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.

Ejemplares similares