Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.

<h4>Objective</h4>Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort.<h4>Patients and methods</...

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Autores principales:	Claes Ohlsson, Mattias Lorentzon, Ensio Norjavaara, Jenny M Kindblom
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a33ca602e49e47c1a63fccb902375362
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spelling	oai:doaj.org-article:a33ca602e49e47c1a63fccb9023753622021-11-18T08:08:44ZAge at adiposity rebound is associated with fat mass in young adult males-the GOOD study.1932-620310.1371/journal.pone.0049404https://doaj.org/article/a33ca602e49e47c1a63fccb9023753622012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166661/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort.<h4>Patients and methods</h4>This is a retrospective cohort study. Detailed growth charts were retrieved for the men participating in the population-based GOOD (Gothenburg Osteoporosis and Obesity Determinants) study (n=573). Body composition was analysed using dual X-ray absorptiometry and computed tomography at 18-20 years of age. Age and BMI at AR were calculated using pediatric growth charts and AR was defined as the lowest BMI between 3 and 9 years of age.<h4>Results</h4>Subjects were divided into early (age at AR below 5.4 years of age), middle (age at AR 5.4 to 6.8 years of age) and late (age at AR after 6.8 years of age) age at AR tertiles. Subjects in the early age at AR tertile had higher young adult BMI (+8%), whole body fat mass (+34%) and amount of subcutaneous adipose tissue (+61%) than the subjects in the middle and late tertiles (p<0.01). The early age at AR tertile had an increased risk of obesity (Odds Ratio 4.1 [95% CI 1.2-13.9]) compared with the middle and late tertiles. In addition, the early age at AR tertile had Peak Height Velocity (PHV) 7 months earlier than the late tertile.<h4>Conclusions</h4>Early age at AR was associated with young adult obesity as a consequence of a high amount of subcutaneous adipose tissue in men. In addition we made the novel observation that early age at AR was associated with an early puberty in men.Claes OhlssonMattias LorentzonEnsio NorjavaaraJenny M KindblomPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49404 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claes Ohlsson Mattias Lorentzon Ensio Norjavaara Jenny M Kindblom Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
description	<h4>Objective</h4>Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort.<h4>Patients and methods</h4>This is a retrospective cohort study. Detailed growth charts were retrieved for the men participating in the population-based GOOD (Gothenburg Osteoporosis and Obesity Determinants) study (n=573). Body composition was analysed using dual X-ray absorptiometry and computed tomography at 18-20 years of age. Age and BMI at AR were calculated using pediatric growth charts and AR was defined as the lowest BMI between 3 and 9 years of age.<h4>Results</h4>Subjects were divided into early (age at AR below 5.4 years of age), middle (age at AR 5.4 to 6.8 years of age) and late (age at AR after 6.8 years of age) age at AR tertiles. Subjects in the early age at AR tertile had higher young adult BMI (+8%), whole body fat mass (+34%) and amount of subcutaneous adipose tissue (+61%) than the subjects in the middle and late tertiles (p<0.01). The early age at AR tertile had an increased risk of obesity (Odds Ratio 4.1 [95% CI 1.2-13.9]) compared with the middle and late tertiles. In addition, the early age at AR tertile had Peak Height Velocity (PHV) 7 months earlier than the late tertile.<h4>Conclusions</h4>Early age at AR was associated with young adult obesity as a consequence of a high amount of subcutaneous adipose tissue in men. In addition we made the novel observation that early age at AR was associated with an early puberty in men.
format	article
author	Claes Ohlsson Mattias Lorentzon Ensio Norjavaara Jenny M Kindblom
author_facet	Claes Ohlsson Mattias Lorentzon Ensio Norjavaara Jenny M Kindblom
author_sort	Claes Ohlsson
title	Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
title_short	Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
title_full	Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
title_fullStr	Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
title_full_unstemmed	Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
title_sort	age at adiposity rebound is associated with fat mass in young adult males-the good study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a33ca602e49e47c1a63fccb902375362
work_keys_str_mv	AT claesohlsson ageatadiposityreboundisassociatedwithfatmassinyoungadultmalesthegoodstudy AT mattiaslorentzon ageatadiposityreboundisassociatedwithfatmassinyoungadultmalesthegoodstudy AT ensionorjavaara ageatadiposityreboundisassociatedwithfatmassinyoungadultmalesthegoodstudy AT jennymkindblom ageatadiposityreboundisassociatedwithfatmassinyoungadultmalesthegoodstudy
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Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.

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