Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon
Daquan Chen1,2, Wanhui Liu1,2, Yan Shen3, Hongjie Mu1,2, Yanchun Zhang4 , Rongcai Liang1,2, Aiping Wang1,2, Kaoxiang Sun1,2, Fenghua Fu1,2 1School of Pharmacy, Yantai University, Yantai, People’s Republic of China; 2State Key Laboratory of Long-acting and Targeting Drug Delivery System...
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Dove Medical Press
2011
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oai:doaj.org-article:a33e7967f0584f5480d1a3474fafe3af2021-12-02T01:23:34ZEffects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon1176-91141178-2013https://doaj.org/article/a33e7967f0584f5480d1a3474fafe3af2011-09-01T00:00:00Zhttp://www.dovepress.com/effects-of-a-novel-ph-sensitive-liposome-with-cleavable-esterase-catal-a8319https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Daquan Chen1,2, Wanhui Liu1,2, Yan Shen3, Hongjie Mu1,2, Yanchun Zhang4 , Rongcai Liang1,2, Aiping Wang1,2, Kaoxiang Sun1,2, Fenghua Fu1,2 1School of Pharmacy, Yantai University, Yantai, People’s Republic of China; 2State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, People’s Republic of China; 3College of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; 4College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei, People’s Republic of China Background: The ABC phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in the liver and spleen. Methods: To clarify this immune response phenomenon, we evaluated a novel modified pH-sensitive liposome with a cleavable double smart PEG-lipid derivative (mPEG-Hz-CHEMS). Results: The ABC phenomenon in mice was brought about by repeated injection of conventional PEG-PE liposomes and was accompanied by a greatly increased uptake in the liver. However, a slight ABC phenomenon was brought about by repeated injection of mPEG-CHEMS liposomes and was accompanied by only a slightly increased uptake in the liver, and repeated injection of mPEG-Hz-CHEMS liposomes did not induce the ABC phenomenon and there was no increase in liver accumulation. This finding indicates that the cleavable mPEG-Hz-CHEMS derivative could lessen or eliminate the ABC phenomenon induced by repeated injection of PEGylated liposomes. Conclusion: This research has shed some light on a solution to the ABC phenomenon using a cleavable PEG-Hz-CHEMS derivative encapsulated in nanoparticles. Keywords: accelerated blood clearance, double smart, cleavable, mPEG-lipid derivates, pH-sensitive liposomeChen DLiu WShen YMu HZhang YLiang RWang ASun KFu FDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2053-2061 (2011) |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Chen D Liu W Shen Y Mu H Zhang Y Liang R Wang A Sun K Fu F Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon |
| description |
Daquan Chen1,2, Wanhui Liu1,2, Yan Shen3, Hongjie Mu1,2, Yanchun Zhang4 , Rongcai Liang1,2, Aiping Wang1,2, Kaoxiang Sun1,2, Fenghua Fu1,2 1School of Pharmacy, Yantai University, Yantai, People’s Republic of China; 2State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, People’s Republic of China; 3College of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China; 4College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei, People’s Republic of China Background: The ABC phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in the liver and spleen. Methods: To clarify this immune response phenomenon, we evaluated a novel modified pH-sensitive liposome with a cleavable double smart PEG-lipid derivative (mPEG-Hz-CHEMS). Results: The ABC phenomenon in mice was brought about by repeated injection of conventional PEG-PE liposomes and was accompanied by a greatly increased uptake in the liver. However, a slight ABC phenomenon was brought about by repeated injection of mPEG-CHEMS liposomes and was accompanied by only a slightly increased uptake in the liver, and repeated injection of mPEG-Hz-CHEMS liposomes did not induce the ABC phenomenon and there was no increase in liver accumulation. This finding indicates that the cleavable mPEG-Hz-CHEMS derivative could lessen or eliminate the ABC phenomenon induced by repeated injection of PEGylated liposomes. Conclusion: This research has shed some light on a solution to the ABC phenomenon using a cleavable PEG-Hz-CHEMS derivative encapsulated in nanoparticles. Keywords: accelerated blood clearance, double smart, cleavable, mPEG-lipid derivates, pH-sensitive liposome |
| format |
article |
| author |
Chen D Liu W Shen Y Mu H Zhang Y Liang R Wang A Sun K Fu F |
| author_facet |
Chen D Liu W Shen Y Mu H Zhang Y Liang R Wang A Sun K Fu F |
| author_sort |
Chen D |
| title |
Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon |
| title_short |
Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon |
| title_full |
Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon |
| title_fullStr |
Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon |
| title_full_unstemmed |
Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon |
| title_sort |
effects of a novel ph-sensitive liposome with cleavable esterase-catalyzed and ph-responsive double smart mpeg lipid derivative on abc phenomenon |
| publisher |
Dove Medical Press |
| publishDate |
2011 |
| url |
https://doaj.org/article/a33e7967f0584f5480d1a3474fafe3af |
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