Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study

Isotretinoin (INN), a drug used to treat severe acne, has anti-inflammatory and antibacterial properties. INN may affect periodontal pathogenic bacteria, so we aimed to study the effect of INN on intraoral microbial profiles of periodontal disease and healthy periodontium. Our case-control study div...

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Autores principales:	Reham AlJasser, Razan AlAqeely, Afnan AlZahrani, Manal AlKenani, Sadeem AlQahtani, Mohammed AlSarhan, Dalal AlOtaibi, Rhodanne Lambarte
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oral microbes periodontal pathogens isotretinoin periodontal therapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a341a3b5b6974b9cb849c345c3ec94ee
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spelling	oai:doaj.org-article:a341a3b5b6974b9cb849c345c3ec94ee2021-11-25T16:21:58ZAntimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study10.3390/antibiotics101112862079-6382https://doaj.org/article/a341a3b5b6974b9cb849c345c3ec94ee2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1286https://doaj.org/toc/2079-6382Isotretinoin (INN), a drug used to treat severe acne, has anti-inflammatory and antibacterial properties. INN may affect periodontal pathogenic bacteria, so we aimed to study the effect of INN on intraoral microbial profiles of periodontal disease and healthy periodontium. Our case-control study divided 180 subjects into six groups according to periodontal health status and INN usage as follows: healthy periodontium receiving INN (HINN; <i>n</i> = 30); those with generalized plaque-induced gingivitis receiving INN (GINN; <i>n</i> = 30); and those with stage I generalized periodontitis receiving INN (PINN; <i>n</i> = 30). Subjects not taking INN, were categorized in the same manner: those with a healthy periodontium (HC; <i>n</i> = 30); those with generalized plaque-induced gingivitis (GC; <i>n</i> = 30); and those with generalized periodontitis stage I (PC; <i>n</i> = 30). Plaque samples were collected to determine the prevalence of four periodontal pathogens (<i>Porphyromonas gingivalis</i>, <i>Tannerella forsythia</i>, <i>Treponema denticola</i>, and <i>Fusobacterium nucleatum)</i> in each study group using real-time polymerase chain reaction. Data were analyzed using IBM SPSS software, and multiple regression analysis was performed for each parameter tested in each group at a significance level of 0.05. All INN groups showed significantly lower levels of <i>P. gingivalis</i>, <i>T. forsythia</i>, and <i>T. denticola</i> and higher levels of <i>F. nucleatum</i> (<i>p <</i> 0.001). INN had an observable antimicrobial effect on the periodontal pathogen count in patients with plaque-induced gingivitis and chronic periodontitis. INN may have a potential additive antimicrobial value in the treatment of periodontal disease.Reham AlJasserRazan AlAqeelyAfnan AlZahraniManal AlKenaniSadeem AlQahtaniMohammed AlSarhanDalal AlOtaibiRhodanne LambarteMDPI AGarticleoral microbesperiodontal pathogensisotretinoinperiodontal therapyTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1286, p 1286 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral microbes periodontal pathogens isotretinoin periodontal therapy Therapeutics. Pharmacology RM1-950
spellingShingle	oral microbes periodontal pathogens isotretinoin periodontal therapy Therapeutics. Pharmacology RM1-950 Reham AlJasser Razan AlAqeely Afnan AlZahrani Manal AlKenani Sadeem AlQahtani Mohammed AlSarhan Dalal AlOtaibi Rhodanne Lambarte Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study
description	Isotretinoin (INN), a drug used to treat severe acne, has anti-inflammatory and antibacterial properties. INN may affect periodontal pathogenic bacteria, so we aimed to study the effect of INN on intraoral microbial profiles of periodontal disease and healthy periodontium. Our case-control study divided 180 subjects into six groups according to periodontal health status and INN usage as follows: healthy periodontium receiving INN (HINN; <i>n</i> = 30); those with generalized plaque-induced gingivitis receiving INN (GINN; <i>n</i> = 30); and those with stage I generalized periodontitis receiving INN (PINN; <i>n</i> = 30). Subjects not taking INN, were categorized in the same manner: those with a healthy periodontium (HC; <i>n</i> = 30); those with generalized plaque-induced gingivitis (GC; <i>n</i> = 30); and those with generalized periodontitis stage I (PC; <i>n</i> = 30). Plaque samples were collected to determine the prevalence of four periodontal pathogens (<i>Porphyromonas gingivalis</i>, <i>Tannerella forsythia</i>, <i>Treponema denticola</i>, and <i>Fusobacterium nucleatum)</i> in each study group using real-time polymerase chain reaction. Data were analyzed using IBM SPSS software, and multiple regression analysis was performed for each parameter tested in each group at a significance level of 0.05. All INN groups showed significantly lower levels of <i>P. gingivalis</i>, <i>T. forsythia</i>, and <i>T. denticola</i> and higher levels of <i>F. nucleatum</i> (<i>p <</i> 0.001). INN had an observable antimicrobial effect on the periodontal pathogen count in patients with plaque-induced gingivitis and chronic periodontitis. INN may have a potential additive antimicrobial value in the treatment of periodontal disease.
format	article
author	Reham AlJasser Razan AlAqeely Afnan AlZahrani Manal AlKenani Sadeem AlQahtani Mohammed AlSarhan Dalal AlOtaibi Rhodanne Lambarte
author_facet	Reham AlJasser Razan AlAqeely Afnan AlZahrani Manal AlKenani Sadeem AlQahtani Mohammed AlSarhan Dalal AlOtaibi Rhodanne Lambarte
author_sort	Reham AlJasser
title	Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study
title_short	Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study
title_full	Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study
title_fullStr	Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study
title_full_unstemmed	Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study
title_sort	antimicrobial effect of isotretinoin therapy on periodontal pathogens: a case-control study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a341a3b5b6974b9cb849c345c3ec94ee
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Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study

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