Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications

Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications

Duplication of chromosome 15q11-q13 is associated with autism spectrum disorder (ASD). Here, the authors show that in mice paternal Dup15q results in ASD-like neuronal and behavioural impairment driven by Necdin.

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Autores principales: Kota Tamada, Keita Fukumoto, Tsuyoshi Toya, Nobuhiro Nakai, Janak R. Awasthi, Shinji Tanaka, Shigeo Okabe, François Spitz, Fumihito Saitow, Hidenori Suzuki, Toru Takumi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a34621df8ce54a06a59e939a043096f2
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spelling oai:doaj.org-article:a34621df8ce54a06a59e939a043096f22021-12-02T16:31:43ZGenetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications10.1038/s41467-021-24359-32041-1723https://doaj.org/article/a34621df8ce54a06a59e939a043096f22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24359-3https://doaj.org/toc/2041-1723Duplication of chromosome 15q11-q13 is associated with autism spectrum disorder (ASD). Here, the authors show that in mice paternal Dup15q results in ASD-like neuronal and behavioural impairment driven by Necdin.Kota TamadaKeita FukumotoTsuyoshi ToyaNobuhiro NakaiJanak R. AwasthiShinji TanakaShigeo OkabeFrançois SpitzFumihito SaitowHidenori SuzukiToru TakumiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kota Tamada
Keita Fukumoto
Tsuyoshi Toya
Nobuhiro Nakai
Janak R. Awasthi
Shinji Tanaka
Shigeo Okabe
François Spitz
Fumihito Saitow
Hidenori Suzuki
Toru Takumi
Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications
description Duplication of chromosome 15q11-q13 is associated with autism spectrum disorder (ASD). Here, the authors show that in mice paternal Dup15q results in ASD-like neuronal and behavioural impairment driven by Necdin.
format article
author Kota Tamada
Keita Fukumoto
Tsuyoshi Toya
Nobuhiro Nakai
Janak R. Awasthi
Shinji Tanaka
Shigeo Okabe
François Spitz
Fumihito Saitow
Hidenori Suzuki
Toru Takumi
author_facet Kota Tamada
Keita Fukumoto
Tsuyoshi Toya
Nobuhiro Nakai
Janak R. Awasthi
Shinji Tanaka
Shigeo Okabe
François Spitz
Fumihito Saitow
Hidenori Suzuki
Toru Takumi
author_sort Kota Tamada
title Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications
title_short Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications
title_full Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications
title_fullStr Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications
title_full_unstemmed Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications
title_sort genetic dissection identifies necdin as a driver gene in a mouse model of paternal 15q duplications
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a34621df8ce54a06a59e939a043096f2
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