The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus

Abstract Although large advances have recently been made mapping out the cellular composition of lung tissue using single cell sequencing, the composition and distribution of the cellular elements within the lining fluid of the lung has not been extensively studied. Here, we assessed the cellular co...

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Autores principales:	S. D. Pouwels, Janette K. Burgess, Erik Verschuuren, Dirk-Jan Slebos
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Bronchoalveolar lavage fluid Epithelial lining fluid Neutrophils Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/a346fd6896964a5da91b43a64605e857
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spelling	oai:doaj.org-article:a346fd6896964a5da91b43a64605e8572021-11-08T11:03:47ZThe cellular composition of the lung lining fluid gradually changes from bronchus to alveolus10.1186/s12931-021-01882-x1465-993Xhttps://doaj.org/article/a346fd6896964a5da91b43a64605e8572021-11-01T00:00:00Zhttps://doi.org/10.1186/s12931-021-01882-xhttps://doaj.org/toc/1465-993XAbstract Although large advances have recently been made mapping out the cellular composition of lung tissue using single cell sequencing, the composition and distribution of the cellular elements within the lining fluid of the lung has not been extensively studied. Here, we assessed the cellular composition of the lung lining fluid by performing a differential cell analysis on bronchoalveolar lavage fluid (BALF) and epithelial lining fluid (ELF) at four different locations within the lung in post-lung transplantation patients. The percentage of neutrophils and lymphocytes is reduced in more distal regions of the lungs, while the percentage of macrophages increases in these more distal regions. These data provide valuable information to determine which lung lining fluid sampling technique and location is best to use for measuring specific factors and biomarkers, and to increase the understanding of different cell populations in specific lung regions.S. D. PouwelsJanette K. BurgessErik VerschuurenDirk-Jan SlebosBMCarticleBronchoalveolar lavage fluidEpithelial lining fluidNeutrophilsDiseases of the respiratory systemRC705-779ENRespiratory Research, Vol 22, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bronchoalveolar lavage fluid Epithelial lining fluid Neutrophils Diseases of the respiratory system RC705-779
spellingShingle	Bronchoalveolar lavage fluid Epithelial lining fluid Neutrophils Diseases of the respiratory system RC705-779 S. D. Pouwels Janette K. Burgess Erik Verschuuren Dirk-Jan Slebos The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus
description	Abstract Although large advances have recently been made mapping out the cellular composition of lung tissue using single cell sequencing, the composition and distribution of the cellular elements within the lining fluid of the lung has not been extensively studied. Here, we assessed the cellular composition of the lung lining fluid by performing a differential cell analysis on bronchoalveolar lavage fluid (BALF) and epithelial lining fluid (ELF) at four different locations within the lung in post-lung transplantation patients. The percentage of neutrophils and lymphocytes is reduced in more distal regions of the lungs, while the percentage of macrophages increases in these more distal regions. These data provide valuable information to determine which lung lining fluid sampling technique and location is best to use for measuring specific factors and biomarkers, and to increase the understanding of different cell populations in specific lung regions.
format	article
author	S. D. Pouwels Janette K. Burgess Erik Verschuuren Dirk-Jan Slebos
author_facet	S. D. Pouwels Janette K. Burgess Erik Verschuuren Dirk-Jan Slebos
author_sort	S. D. Pouwels
title	The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus
title_short	The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus
title_full	The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus
title_fullStr	The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus
title_full_unstemmed	The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus
title_sort	cellular composition of the lung lining fluid gradually changes from bronchus to alveolus
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a346fd6896964a5da91b43a64605e857
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The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus

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