Japanese encephalitis-a pathological and clinical perspective.

Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tro...

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Autores principales:	Debapriya Ghosh, Anirban Basu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/a34fe68830824a90ab2c9bb4e03d1f20
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spelling	oai:doaj.org-article:a34fe68830824a90ab2c9bb4e03d1f202021-11-25T06:33:10ZJapanese encephalitis-a pathological and clinical perspective.1935-27271935-273510.1371/journal.pntd.0000437https://doaj.org/article/a34fe68830824a90ab2c9bb4e03d1f202009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19787040/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncommon in the West. With rapid globalization and climatic shift, JEV has started to emerge in areas where the threat was previously unknown. Scientific evidence predicts that JEV will soon become a global pathogen and cause of worldwide pandemics. Although some research documents JEV pathogenesis and drug discovery, worldwide awareness of the need for extensive research to deal with JE is still lacking. This review focuses on the exigency of developing a worldwide effort to acknowledge the prime importance of performing an extensive study of this thus far neglected tropical viral disease. This review also outlines the pathogenesis, the scientific efforts channeled into develop a therapy, and the outlook for a possible future breakthrough addressing this killer disease.Debapriya GhoshAnirban BasuPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 3, Iss 9, p e437 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Debapriya Ghosh Anirban Basu Japanese encephalitis-a pathological and clinical perspective.
description	Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncommon in the West. With rapid globalization and climatic shift, JEV has started to emerge in areas where the threat was previously unknown. Scientific evidence predicts that JEV will soon become a global pathogen and cause of worldwide pandemics. Although some research documents JEV pathogenesis and drug discovery, worldwide awareness of the need for extensive research to deal with JE is still lacking. This review focuses on the exigency of developing a worldwide effort to acknowledge the prime importance of performing an extensive study of this thus far neglected tropical viral disease. This review also outlines the pathogenesis, the scientific efforts channeled into develop a therapy, and the outlook for a possible future breakthrough addressing this killer disease.
format	article
author	Debapriya Ghosh Anirban Basu
author_facet	Debapriya Ghosh Anirban Basu
author_sort	Debapriya Ghosh
title	Japanese encephalitis-a pathological and clinical perspective.
title_short	Japanese encephalitis-a pathological and clinical perspective.
title_full	Japanese encephalitis-a pathological and clinical perspective.
title_fullStr	Japanese encephalitis-a pathological and clinical perspective.
title_full_unstemmed	Japanese encephalitis-a pathological and clinical perspective.
title_sort	japanese encephalitis-a pathological and clinical perspective.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/a34fe68830824a90ab2c9bb4e03d1f20
work_keys_str_mv	AT debapriyaghosh japaneseencephalitisapathologicalandclinicalperspective AT anirbanbasu japaneseencephalitisapathologicalandclinicalperspective
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Japanese encephalitis-a pathological and clinical perspective.

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