Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation

Abstract The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	In-Ho Bae, Myung Ho Jeong, Kyung Seob Lim, Dae Sung Park, Jae Won Shim, Jun-Kyu Park, Kwang Hwan Oh, Mi Rim Jin, Doo Sun Sim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a350853d57f14cf39c8d72c1c181b0af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a350853d57f14cf39c8d72c1c181b0af
record_format	dspace
spelling	oai:doaj.org-article:a350853d57f14cf39c8d72c1c181b0af2021-12-02T15:08:35ZNovel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation10.1038/s41598-018-25629-92045-2322https://doaj.org/article/a350853d57f14cf39c8d72c1c181b0af2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25629-9https://doaj.org/toc/2045-2322Abstract The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) and smooth muscle cell response. Animal study was performed using a porcine coronary restenosis model. The study groups were divided into 1) bare metal stent (BMS), 2) poly(L-lactide) (PLA)-based EVL drug eluting stent (DES), 3) commercial EVL-eluting DES, and 4) FSL-EVL-DES. After four weeks of stent implantation, various analyses were performed. Quantitative analysis showed that the amount of in-stent restenosis was higher in the BMS group (BMS; 27.8 ± 2.68%, PLA-based DES; 12.2 ± 0.57%, commercial DES; 9.8 ± 0.28%, and FSL-DES; 9.3 ± 0.25%, n = 10, p < 0.05). Specifically, the inflammation score was reduced in the FSL-DES group (1.9 ± 0.39, n = 10, p < 0.05). The increment in re-endothelialization in the FSL-DES group was confirmed by immunofluorescence analysis. Taken together, the novel polymer-free EVL-eluting stent fabricated using FSL can be an innovative DES with reduced risk of ISR, thrombosis, and inflammation.In-Ho BaeMyung Ho JeongKyung Seob LimDae Sung ParkJae Won ShimJun-Kyu ParkKwang Hwan OhMi Rim JinDoo Sun SimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q In-Ho Bae Myung Ho Jeong Kyung Seob Lim Dae Sung Park Jae Won Shim Jun-Kyu Park Kwang Hwan Oh Mi Rim Jin Doo Sun Sim Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation
description	Abstract The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) and smooth muscle cell response. Animal study was performed using a porcine coronary restenosis model. The study groups were divided into 1) bare metal stent (BMS), 2) poly(L-lactide) (PLA)-based EVL drug eluting stent (DES), 3) commercial EVL-eluting DES, and 4) FSL-EVL-DES. After four weeks of stent implantation, various analyses were performed. Quantitative analysis showed that the amount of in-stent restenosis was higher in the BMS group (BMS; 27.8 ± 2.68%, PLA-based DES; 12.2 ± 0.57%, commercial DES; 9.8 ± 0.28%, and FSL-DES; 9.3 ± 0.25%, n = 10, p < 0.05). Specifically, the inflammation score was reduced in the FSL-DES group (1.9 ± 0.39, n = 10, p < 0.05). The increment in re-endothelialization in the FSL-DES group was confirmed by immunofluorescence analysis. Taken together, the novel polymer-free EVL-eluting stent fabricated using FSL can be an innovative DES with reduced risk of ISR, thrombosis, and inflammation.
format	article
author	In-Ho Bae Myung Ho Jeong Kyung Seob Lim Dae Sung Park Jae Won Shim Jun-Kyu Park Kwang Hwan Oh Mi Rim Jin Doo Sun Sim
author_facet	In-Ho Bae Myung Ho Jeong Kyung Seob Lim Dae Sung Park Jae Won Shim Jun-Kyu Park Kwang Hwan Oh Mi Rim Jin Doo Sun Sim
author_sort	In-Ho Bae
title	Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation
title_short	Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation
title_full	Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation
title_fullStr	Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation
title_full_unstemmed	Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation
title_sort	novel polymer-free everolimus-eluting stent fabricated using femtosecond laser improves re-endothelialization and anti-inflammation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a350853d57f14cf39c8d72c1c181b0af
work_keys_str_mv	AT inhobae novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT myunghojeong novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT kyungseoblim novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT daesungpark novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT jaewonshim novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT junkyupark novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT kwanghwanoh novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT mirimjin novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation AT doosunsim novelpolymerfreeeverolimuselutingstentfabricatedusingfemtosecondlaserimprovesreendothelializationandantiinflammation
_version_	1718388077866516480

Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation

Ejemplares similares