Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription

The molecular mechanisms of memory storage remain poorly understood. In this study, authors describe a new mechanism that regulates the cellular patterns of early response gene signaling during learning via the recruitment of two functionally redundant nuclear repressors, class IIa histone deacetyla...

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Autores principales:	Yongchuan Zhu, Min Huang, Eric Bushong, Sebastien Phan, Marco Uytiepo, Elizabeth Beutter, Daniel Boemer, Kristin Tsui, Mark Ellisman, Anton Maximov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3516b0fa6ed4f2a9969586cc281ce01
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spelling	oai:doaj.org-article:a3516b0fa6ed4f2a9969586cc281ce012021-12-02T16:57:44ZClass IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription10.1038/s41467-019-11409-02041-1723https://doaj.org/article/a3516b0fa6ed4f2a9969586cc281ce012019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11409-0https://doaj.org/toc/2041-1723The molecular mechanisms of memory storage remain poorly understood. In this study, authors describe a new mechanism that regulates the cellular patterns of early response gene signaling during learning via the recruitment of two functionally redundant nuclear repressors, class IIa histone deacetylases (HDACs) 4 and 5Yongchuan ZhuMin HuangEric BushongSebastien PhanMarco UytiepoElizabeth BeutterDaniel BoemerKristin TsuiMark EllismanAnton MaximovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongchuan Zhu Min Huang Eric Bushong Sebastien Phan Marco Uytiepo Elizabeth Beutter Daniel Boemer Kristin Tsui Mark Ellisman Anton Maximov Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
description	The molecular mechanisms of memory storage remain poorly understood. In this study, authors describe a new mechanism that regulates the cellular patterns of early response gene signaling during learning via the recruitment of two functionally redundant nuclear repressors, class IIa histone deacetylases (HDACs) 4 and 5
format	article
author	Yongchuan Zhu Min Huang Eric Bushong Sebastien Phan Marco Uytiepo Elizabeth Beutter Daniel Boemer Kristin Tsui Mark Ellisman Anton Maximov
author_facet	Yongchuan Zhu Min Huang Eric Bushong Sebastien Phan Marco Uytiepo Elizabeth Beutter Daniel Boemer Kristin Tsui Mark Ellisman Anton Maximov
author_sort	Yongchuan Zhu
title	Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
title_short	Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
title_full	Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
title_fullStr	Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
title_full_unstemmed	Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
title_sort	class iia hdacs regulate learning and memory through dynamic experience-dependent repression of transcription
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a3516b0fa6ed4f2a9969586cc281ce01
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Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription

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