Vitamin D and immunomodulation in the skin: a useful affirmative nexus

Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune response, inflammation, tolerogenic capacity, wound healing, etc. The immune cells of the skin exhibit...

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Autor principal:	Saptadip Samanta
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	vitamin d skin immunomodulation cytokines anti-inflammatory effects calcipotriol Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a351de15423a4f189f3e609dfa6bb27f
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spelling	oai:doaj.org-article:a351de15423a4f189f3e609dfa6bb27f2021-11-24T05:56:58ZVitamin D and immunomodulation in the skin: a useful affirmative nexus10.37349/ei.2021.000092768-6655https://doaj.org/article/a351de15423a4f189f3e609dfa6bb27f2021-06-01T00:00:00Zhttps://www.explorationpub.com/Journals/ei/Article/10039https://doaj.org/toc/2768-6655Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune response, inflammation, tolerogenic capacity, wound healing, etc. The immune cells of the skin exhibit distinct properties. They can synthesize active vitamin D [1,24(OH)2D3] and express vitamin D receptors. Any difficulties in the cutaneous immune system cause skin diseases (psoriasis, vitiligo, atopic dermatitis, skin carcinoma, and others). Vitamin D is an essential factor, exhibits immunomodulatory effects by regulating dendritic cells’ maturation, lymphocytes’ functions, and cytokine production. More specifically, vitamin D acts as an immune balancing agent, inhibits the exaggeration of immunostimulation. This vitamin suppresses T-helper 1 and T-helper 17 cell formation decreases inflammatory cytokines release and promotes the maturation of regulatory T cells and interleukin 10 secretion. The deficiency of this vitamin promotes the occurrence of immunoreactive disorders. Administration of vitamin D or its analogs is the therapeutic choice for the treatment of several skin diseases.Saptadip SamantaOpen Exploration Publishing Inc.articlevitamin dskinimmunomodulationcytokinesanti-inflammatory effectscalcipotriolImmunologic diseases. AllergyRC581-607ENExploration of Immunology, Vol 1, Iss 2, Pp 90-111 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d skin immunomodulation cytokines anti-inflammatory effects calcipotriol Immunologic diseases. Allergy RC581-607
spellingShingle	vitamin d skin immunomodulation cytokines anti-inflammatory effects calcipotriol Immunologic diseases. Allergy RC581-607 Saptadip Samanta Vitamin D and immunomodulation in the skin: a useful affirmative nexus
description	Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune response, inflammation, tolerogenic capacity, wound healing, etc. The immune cells of the skin exhibit distinct properties. They can synthesize active vitamin D [1,24(OH)2D3] and express vitamin D receptors. Any difficulties in the cutaneous immune system cause skin diseases (psoriasis, vitiligo, atopic dermatitis, skin carcinoma, and others). Vitamin D is an essential factor, exhibits immunomodulatory effects by regulating dendritic cells’ maturation, lymphocytes’ functions, and cytokine production. More specifically, vitamin D acts as an immune balancing agent, inhibits the exaggeration of immunostimulation. This vitamin suppresses T-helper 1 and T-helper 17 cell formation decreases inflammatory cytokines release and promotes the maturation of regulatory T cells and interleukin 10 secretion. The deficiency of this vitamin promotes the occurrence of immunoreactive disorders. Administration of vitamin D or its analogs is the therapeutic choice for the treatment of several skin diseases.
format	article
author	Saptadip Samanta
author_facet	Saptadip Samanta
author_sort	Saptadip Samanta
title	Vitamin D and immunomodulation in the skin: a useful affirmative nexus
title_short	Vitamin D and immunomodulation in the skin: a useful affirmative nexus
title_full	Vitamin D and immunomodulation in the skin: a useful affirmative nexus
title_fullStr	Vitamin D and immunomodulation in the skin: a useful affirmative nexus
title_full_unstemmed	Vitamin D and immunomodulation in the skin: a useful affirmative nexus
title_sort	vitamin d and immunomodulation in the skin: a useful affirmative nexus
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/a351de15423a4f189f3e609dfa6bb27f
work_keys_str_mv	AT saptadipsamanta vitamindandimmunomodulationintheskinausefulaffirmativenexus
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Vitamin D and immunomodulation in the skin: a useful affirmative nexus

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