Features of Food Hypersensitivity in Children with Autism Spectrum Disorder

Currently, the incidence of autism spectrum disorders (ASD) continues to increase in the children’s population. However, the pathogenesis of autism remains controversial.The purpose of this work is to evaluate the performance of the elimination nutritional approaches to the dynamics of indicators of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. I. Khudiakova, N. A. Cherevko, A. V. Skirnevskaia, M. Yu. Rozenshtein, A. Z. Rozenshtein, S. E. Kondakov, K. V. Berezovskaia
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	autism spectrum disorder food hypersensitivity personalized elimination diet interleukins Science Q
Acceso en línea:	https://doaj.org/article/a35394941ba54d99bf2e2bc4e9f736f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a35394941ba54d99bf2e2bc4e9f736f1
record_format	dspace
spelling	oai:doaj.org-article:a35394941ba54d99bf2e2bc4e9f736f12021-11-23T06:14:43ZFeatures of Food Hypersensitivity in Children with Autism Spectrum Disorder2541-94202587-959610.29413/ABS.2019-4.5.10https://doaj.org/article/a35394941ba54d99bf2e2bc4e9f736f12019-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2171https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Currently, the incidence of autism spectrum disorders (ASD) continues to increase in the children’s population. However, the pathogenesis of autism remains controversial.The purpose of this work is to evaluate the performance of the elimination nutritional approaches to the dynamics of indicators of food hypersensitivity, the balance of interleukins and psychophysiological parameters in children with ASD.Methods. A prospective cohort study of children aged 7 ± 2 years, healthy and diagnosed with ASD was performed. Determination of specific immunoglobulin concentrations to 111 food antigens and interleukins was measured by ELISA. Psychophysiological indicators of communicative competence in children with ASD were evaluated in the ATEC-test.Results. It was established that in children with ASD (n = 69), the frequency of occurrence of food hypersensitivity and indicators of specific sIgG concentrations to food antigens of dairy and grain products are higher (р < 0.05). A direct correlation was found between the concentration of INFγ, IgG concentrations to antigens of dairy, grain products and C. albicans. High ratios of the INFγ/IL4 and INFγ/IL10 ratios (p < 0.05) were revealed. As a result of compliance with the elimination diet was noted significant decrease in the concentration of sIgG to food antigens, sIgG to C. albicans, changes indicators following the results of ATEC testing.The data obtained revealed the unexplored effects the influence of specific food hypersensitivity on the process of initiation and maintenance of immune inflammation, as well as on the communicative competence in pathological conditions. A personalized elimination diet can improve the immunorehabilitation and the quality of life of children with autism.M. I. KhudiakovaN. A. CherevkoA. V. SkirnevskaiaM. Yu. RozenshteinA. Z. RozenshteinS. E. KondakovK. V. BerezovskaiaScientific Сentre for Family Health and Human Reproduction Problemsarticleautism spectrum disorderfood hypersensitivitypersonalized elimination dietinterleukinsScienceQRUActa Biomedica Scientifica, Vol 4, Iss 5, Pp 60-67 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	autism spectrum disorder food hypersensitivity personalized elimination diet interleukins Science Q
spellingShingle	autism spectrum disorder food hypersensitivity personalized elimination diet interleukins Science Q M. I. Khudiakova N. A. Cherevko A. V. Skirnevskaia M. Yu. Rozenshtein A. Z. Rozenshtein S. E. Kondakov K. V. Berezovskaia Features of Food Hypersensitivity in Children with Autism Spectrum Disorder
description	Currently, the incidence of autism spectrum disorders (ASD) continues to increase in the children’s population. However, the pathogenesis of autism remains controversial.The purpose of this work is to evaluate the performance of the elimination nutritional approaches to the dynamics of indicators of food hypersensitivity, the balance of interleukins and psychophysiological parameters in children with ASD.Methods. A prospective cohort study of children aged 7 ± 2 years, healthy and diagnosed with ASD was performed. Determination of specific immunoglobulin concentrations to 111 food antigens and interleukins was measured by ELISA. Psychophysiological indicators of communicative competence in children with ASD were evaluated in the ATEC-test.Results. It was established that in children with ASD (n = 69), the frequency of occurrence of food hypersensitivity and indicators of specific sIgG concentrations to food antigens of dairy and grain products are higher (р < 0.05). A direct correlation was found between the concentration of INFγ, IgG concentrations to antigens of dairy, grain products and C. albicans. High ratios of the INFγ/IL4 and INFγ/IL10 ratios (p < 0.05) were revealed. As a result of compliance with the elimination diet was noted significant decrease in the concentration of sIgG to food antigens, sIgG to C. albicans, changes indicators following the results of ATEC testing.The data obtained revealed the unexplored effects the influence of specific food hypersensitivity on the process of initiation and maintenance of immune inflammation, as well as on the communicative competence in pathological conditions. A personalized elimination diet can improve the immunorehabilitation and the quality of life of children with autism.
format	article
author	M. I. Khudiakova N. A. Cherevko A. V. Skirnevskaia M. Yu. Rozenshtein A. Z. Rozenshtein S. E. Kondakov K. V. Berezovskaia
author_facet	M. I. Khudiakova N. A. Cherevko A. V. Skirnevskaia M. Yu. Rozenshtein A. Z. Rozenshtein S. E. Kondakov K. V. Berezovskaia
author_sort	M. I. Khudiakova
title	Features of Food Hypersensitivity in Children with Autism Spectrum Disorder
title_short	Features of Food Hypersensitivity in Children with Autism Spectrum Disorder
title_full	Features of Food Hypersensitivity in Children with Autism Spectrum Disorder
title_fullStr	Features of Food Hypersensitivity in Children with Autism Spectrum Disorder
title_full_unstemmed	Features of Food Hypersensitivity in Children with Autism Spectrum Disorder
title_sort	features of food hypersensitivity in children with autism spectrum disorder
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/a35394941ba54d99bf2e2bc4e9f736f1
work_keys_str_mv	AT mikhudiakova featuresoffoodhypersensitivityinchildrenwithautismspectrumdisorder AT nacherevko featuresoffoodhypersensitivityinchildrenwithautismspectrumdisorder AT avskirnevskaia featuresoffoodhypersensitivityinchildrenwithautismspectrumdisorder AT myurozenshtein featuresoffoodhypersensitivityinchildrenwithautismspectrumdisorder AT azrozenshtein featuresoffoodhypersensitivityinchildrenwithautismspectrumdisorder AT sekondakov featuresoffoodhypersensitivityinchildrenwithautismspectrumdisorder AT kvberezovskaia featuresoffoodhypersensitivityinchildrenwithautismspectrumdisorder
_version_	1718416965630951424

Features of Food Hypersensitivity in Children with Autism Spectrum Disorder

Ejemplares similares