Structural insights into chaperone addiction of toxin-antitoxin systems

SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in c...

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Autores principales:	Valérie Guillet, Patricia Bordes, Cécile Bon, Julien Marcoux, Virginie Gervais, Ambre Julie Sala, Suzana Dos Reis, Nawel Slama, Israel Mares-Mejía, Anne-Marie Cirinesi, Laurent Maveyraud, Pierre Genevaux, Lionel Mourey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3545627c95b4aebbc2831156701c6af
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spelling	oai:doaj.org-article:a3545627c95b4aebbc2831156701c6af2021-12-02T16:57:24ZStructural insights into chaperone addiction of toxin-antitoxin systems10.1038/s41467-019-08747-42041-1723https://doaj.org/article/a3545627c95b4aebbc2831156701c6af2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08747-4https://doaj.org/toc/2041-1723SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in complex with the C-terminal ChAD (chaperone addiction) extension of the antitoxin HigA1.Valérie GuilletPatricia BordesCécile BonJulien MarcouxVirginie GervaisAmbre Julie SalaSuzana Dos ReisNawel SlamaIsrael Mares-MejíaAnne-Marie CirinesiLaurent MaveyraudPierre GenevauxLionel MoureyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valérie Guillet Patricia Bordes Cécile Bon Julien Marcoux Virginie Gervais Ambre Julie Sala Suzana Dos Reis Nawel Slama Israel Mares-Mejía Anne-Marie Cirinesi Laurent Maveyraud Pierre Genevaux Lionel Mourey Structural insights into chaperone addiction of toxin-antitoxin systems
description	SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in complex with the C-terminal ChAD (chaperone addiction) extension of the antitoxin HigA1.
format	article
author	Valérie Guillet Patricia Bordes Cécile Bon Julien Marcoux Virginie Gervais Ambre Julie Sala Suzana Dos Reis Nawel Slama Israel Mares-Mejía Anne-Marie Cirinesi Laurent Maveyraud Pierre Genevaux Lionel Mourey
author_facet	Valérie Guillet Patricia Bordes Cécile Bon Julien Marcoux Virginie Gervais Ambre Julie Sala Suzana Dos Reis Nawel Slama Israel Mares-Mejía Anne-Marie Cirinesi Laurent Maveyraud Pierre Genevaux Lionel Mourey
author_sort	Valérie Guillet
title	Structural insights into chaperone addiction of toxin-antitoxin systems
title_short	Structural insights into chaperone addiction of toxin-antitoxin systems
title_full	Structural insights into chaperone addiction of toxin-antitoxin systems
title_fullStr	Structural insights into chaperone addiction of toxin-antitoxin systems
title_full_unstemmed	Structural insights into chaperone addiction of toxin-antitoxin systems
title_sort	structural insights into chaperone addiction of toxin-antitoxin systems
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a3545627c95b4aebbc2831156701c6af
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Structural insights into chaperone addiction of toxin-antitoxin systems

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