Clinical and immunological characteristic of natural course at the early stages of HIV infection

An early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection inc...

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Autores principales:	E. R. Manapova, V. Kh. Fazylov, A. T. Beshimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	hiv infection hcv-infection early stages hcv/hiv-coinfection cd4<sup>+</sup> lymphocytes cd8<sup>+</sup> lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a3546df037494b979efeb2553a83da25
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spelling	oai:doaj.org-article:a3546df037494b979efeb2553a83da252021-11-18T08:03:49ZClinical and immunological characteristic of natural course at the early stages of HIV infection1563-06252313-741X10.15789/1563-0625-CAI-1866https://doaj.org/article/a3546df037494b979efeb2553a83da252020-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1866https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAn early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection included 25 cases of HCV/HIV-infected patients (first group), and 20 cases with HIV mono-infection (second group). Duration of infection was less than 1 year (with positive ELISA test), with mean terms of HIV immunoblot positivity of 5.5±0.6 months. For comparative analysis, the natural course group was examined, i.e., 43 patients with combined HCV/HIV infection (third group), and 49, with HIV monoinfection (fourth group) with a duration of HIV infection for 4.4±0.21 years. The group of healthy controls included 52 persons. We aimed to perform a comparative evaluation of clinical course and immunological features from the early stages of infection in the patients with combined HCV/HIV and HIV infection. Results: at early stages of infection, clinical pattern in HCV/HIV-infected patients was dominated by purulent-inflammatory, fungal infections and secondary diseases, along with more pronounced inhibition of cellular immunity and increased viral load of RNA HIV, as compared to data on HIV-infected patients.E. R. ManapovaV. Kh. FazylovA. T. BeshimovSPb RAACIarticlehiv infectionhcv-infectionearly stageshcv/hiv-coinfectioncd4<sup>+</sup> lymphocytescd8<sup>+</sup> lymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 3, Pp 519-526 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv infection hcv-infection early stages hcv/hiv-coinfection cd4<sup>+</sup> lymphocytes cd8<sup>+</sup> lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	hiv infection hcv-infection early stages hcv/hiv-coinfection cd4<sup>+</sup> lymphocytes cd8<sup>+</sup> lymphocytes Immunologic diseases. Allergy RC581-607 E. R. Manapova V. Kh. Fazylov A. T. Beshimov Clinical and immunological characteristic of natural course at the early stages of HIV infection
description	An early-stage infection induces the most powerful reactions of immune system. 137 clinical histories of patients with HIV infection, and HCV/HIV-infected at the early stages of HIV infection were subjected to analysis. Patients and methods: a group of 45 patients at early terms of HIV infection included 25 cases of HCV/HIV-infected patients (first group), and 20 cases with HIV mono-infection (second group). Duration of infection was less than 1 year (with positive ELISA test), with mean terms of HIV immunoblot positivity of 5.5±0.6 months. For comparative analysis, the natural course group was examined, i.e., 43 patients with combined HCV/HIV infection (third group), and 49, with HIV monoinfection (fourth group) with a duration of HIV infection for 4.4±0.21 years. The group of healthy controls included 52 persons. We aimed to perform a comparative evaluation of clinical course and immunological features from the early stages of infection in the patients with combined HCV/HIV and HIV infection. Results: at early stages of infection, clinical pattern in HCV/HIV-infected patients was dominated by purulent-inflammatory, fungal infections and secondary diseases, along with more pronounced inhibition of cellular immunity and increased viral load of RNA HIV, as compared to data on HIV-infected patients.
format	article
author	E. R. Manapova V. Kh. Fazylov A. T. Beshimov
author_facet	E. R. Manapova V. Kh. Fazylov A. T. Beshimov
author_sort	E. R. Manapova
title	Clinical and immunological characteristic of natural course at the early stages of HIV infection
title_short	Clinical and immunological characteristic of natural course at the early stages of HIV infection
title_full	Clinical and immunological characteristic of natural course at the early stages of HIV infection
title_fullStr	Clinical and immunological characteristic of natural course at the early stages of HIV infection
title_full_unstemmed	Clinical and immunological characteristic of natural course at the early stages of HIV infection
title_sort	clinical and immunological characteristic of natural course at the early stages of hiv infection
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/a3546df037494b979efeb2553a83da25
work_keys_str_mv	AT ermanapova clinicalandimmunologicalcharacteristicofnaturalcourseattheearlystagesofhivinfection AT vkhfazylov clinicalandimmunologicalcharacteristicofnaturalcourseattheearlystagesofhivinfection AT atbeshimov clinicalandimmunologicalcharacteristicofnaturalcourseattheearlystagesofhivinfection
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Clinical and immunological characteristic of natural course at the early stages of HIV infection

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