Vitamin D deficiency and cardiovascular risk in type 2 diabetes population

This study aims to assess vitamin D deficiency-induced dyslipidemia and cardiovascular disease (CVD) risk in poor glycemic control among type 2 diabetes mellitus (T2DM) patients. This study was carried out among 455 T2DM patients involving poor glycemic control (n = 247) and good glycemic control (n...

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Autores principales:	Pokhrel Sushant, Giri Nisha, Pokhrel Rakesh, Pardhe Bashu Dev, Lamichhane Anit, Chaudhary Abhisek, Bhatt Mahendra Prasad
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	vitamin d dyslipidemia glycemic control type 2 diabetes mellitus Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a3592384495949ccba321f220def2a2f
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spelling	oai:doaj.org-article:a3592384495949ccba321f220def2a2f2021-12-05T14:10:41ZVitamin D deficiency and cardiovascular risk in type 2 diabetes population2391-541210.1515/biol-2021-0050https://doaj.org/article/a3592384495949ccba321f220def2a2f2021-05-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0050https://doaj.org/toc/2391-5412This study aims to assess vitamin D deficiency-induced dyslipidemia and cardiovascular disease (CVD) risk in poor glycemic control among type 2 diabetes mellitus (T2DM) patients. This study was carried out among 455 T2DM patients involving poor glycemic control (n = 247) and good glycemic control (n = 208). Fasting plasma glucose (FPG) and HbA1c were measured to assess glycemic control. Cardiac risk ratio, atherogenic index plasma, and atherogenic coefficient were calculated to assess and compare the CVD risk in different groups. Patients with poor control had a significantly higher level of total cholesterol (TC), triglyceride (TG), and non-high-density lipoprotein lipase cholesterol (non-HDL-C), atherogenic variables, and lower level of high-density lipoprotein lipase cholesterol (HDL-C) as compared to patients with good glycemic control. We also observed significant negative correlation of vitamin D with lipid markers and atherogenic variables in poor glycemic control diabetic population. The serum vitamin D levels were inversely associated with HbA1c, FPG, TG, TC, and non-HDL-C. Furthermore, hypercholesterolemia, hypertriglyceridemia, and elevated non-HDL-C were the independent risks in hypovitaminosis D population. Vitamin D deficiency in poor glycemic control is likely to develop dyslipidemia as compared to vitamin D insufficient and sufficient groups. Thus, vitamin D supplementation and an increase in exposure to sunlight may reduce the risk of cardiovascular complications in diabetes.Pokhrel SushantGiri NishaPokhrel RakeshPardhe Bashu DevLamichhane AnitChaudhary AbhisekBhatt Mahendra PrasadDe Gruyterarticlevitamin ddyslipidemiaglycemic controltype 2 diabetes mellitusBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 464-474 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d dyslipidemia glycemic control type 2 diabetes mellitus Biology (General) QH301-705.5
spellingShingle	vitamin d dyslipidemia glycemic control type 2 diabetes mellitus Biology (General) QH301-705.5 Pokhrel Sushant Giri Nisha Pokhrel Rakesh Pardhe Bashu Dev Lamichhane Anit Chaudhary Abhisek Bhatt Mahendra Prasad Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
description	This study aims to assess vitamin D deficiency-induced dyslipidemia and cardiovascular disease (CVD) risk in poor glycemic control among type 2 diabetes mellitus (T2DM) patients. This study was carried out among 455 T2DM patients involving poor glycemic control (n = 247) and good glycemic control (n = 208). Fasting plasma glucose (FPG) and HbA1c were measured to assess glycemic control. Cardiac risk ratio, atherogenic index plasma, and atherogenic coefficient were calculated to assess and compare the CVD risk in different groups. Patients with poor control had a significantly higher level of total cholesterol (TC), triglyceride (TG), and non-high-density lipoprotein lipase cholesterol (non-HDL-C), atherogenic variables, and lower level of high-density lipoprotein lipase cholesterol (HDL-C) as compared to patients with good glycemic control. We also observed significant negative correlation of vitamin D with lipid markers and atherogenic variables in poor glycemic control diabetic population. The serum vitamin D levels were inversely associated with HbA1c, FPG, TG, TC, and non-HDL-C. Furthermore, hypercholesterolemia, hypertriglyceridemia, and elevated non-HDL-C were the independent risks in hypovitaminosis D population. Vitamin D deficiency in poor glycemic control is likely to develop dyslipidemia as compared to vitamin D insufficient and sufficient groups. Thus, vitamin D supplementation and an increase in exposure to sunlight may reduce the risk of cardiovascular complications in diabetes.
format	article
author	Pokhrel Sushant Giri Nisha Pokhrel Rakesh Pardhe Bashu Dev Lamichhane Anit Chaudhary Abhisek Bhatt Mahendra Prasad
author_facet	Pokhrel Sushant Giri Nisha Pokhrel Rakesh Pardhe Bashu Dev Lamichhane Anit Chaudhary Abhisek Bhatt Mahendra Prasad
author_sort	Pokhrel Sushant
title	Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
title_short	Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
title_full	Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
title_fullStr	Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
title_full_unstemmed	Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
title_sort	vitamin d deficiency and cardiovascular risk in type 2 diabetes population
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/a3592384495949ccba321f220def2a2f
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Vitamin D deficiency and cardiovascular risk in type 2 diabetes population

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