Urinary Protein and Peptide Markers in Chronic Kidney Disease

Chronic kidney disease (CKD) is a non-specific type of kidney disease that causes a gradual decline in kidney function (from months to years). CKD is a significant risk factor for death, cardiovascular disease, and end-stage renal disease. CKDs of different origins may have the same clinical and lab...

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Autores principales:	Natalia Chebotareva, Anatoliy Vinogradov, Valerie McDonnell, Natalia V. Zakharova, Maria I. Indeykina, Sergey Moiseev, Evgeny N. Nikolaev, Alexey S. Kononikhin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biomarkers urine proteomics chronic kidney disease Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a35a320973624eec8544317947641a25
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spelling	oai:doaj.org-article:a35a320973624eec8544317947641a252021-11-25T17:53:34ZUrinary Protein and Peptide Markers in Chronic Kidney Disease10.3390/ijms2222121231422-00671661-6596https://doaj.org/article/a35a320973624eec8544317947641a252021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12123https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Chronic kidney disease (CKD) is a non-specific type of kidney disease that causes a gradual decline in kidney function (from months to years). CKD is a significant risk factor for death, cardiovascular disease, and end-stage renal disease. CKDs of different origins may have the same clinical and laboratory manifestations but different progression rates, which requires early diagnosis to determine. This review focuses on protein/peptide biomarkers of the leading causes of CKD: diabetic nephropathy, IgA nephropathy, lupus nephritis, focal segmental glomerulosclerosis, and membranous nephropathy. Mass spectrometry (MS) approaches provided the most information about urinary peptide and protein contents in different nephropathies. New analytical approaches allow urinary proteomic–peptide profiles to be used as early non-invasive diagnostic tools for specific morphological forms of kidney disease and may become a safe alternative to renal biopsy. MS studies of the key pathogenetic mechanisms of renal disease progression may also contribute to developing new approaches for targeted therapy.Natalia ChebotarevaAnatoliy VinogradovValerie McDonnellNatalia V. ZakharovaMaria I. IndeykinaSergey MoiseevEvgeny N. NikolaevAlexey S. KononikhinMDPI AGarticlebiomarkersurineproteomicschronic kidney diseaseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12123, p 12123 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarkers urine proteomics chronic kidney disease Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	biomarkers urine proteomics chronic kidney disease Biology (General) QH301-705.5 Chemistry QD1-999 Natalia Chebotareva Anatoliy Vinogradov Valerie McDonnell Natalia V. Zakharova Maria I. Indeykina Sergey Moiseev Evgeny N. Nikolaev Alexey S. Kononikhin Urinary Protein and Peptide Markers in Chronic Kidney Disease
description	Chronic kidney disease (CKD) is a non-specific type of kidney disease that causes a gradual decline in kidney function (from months to years). CKD is a significant risk factor for death, cardiovascular disease, and end-stage renal disease. CKDs of different origins may have the same clinical and laboratory manifestations but different progression rates, which requires early diagnosis to determine. This review focuses on protein/peptide biomarkers of the leading causes of CKD: diabetic nephropathy, IgA nephropathy, lupus nephritis, focal segmental glomerulosclerosis, and membranous nephropathy. Mass spectrometry (MS) approaches provided the most information about urinary peptide and protein contents in different nephropathies. New analytical approaches allow urinary proteomic–peptide profiles to be used as early non-invasive diagnostic tools for specific morphological forms of kidney disease and may become a safe alternative to renal biopsy. MS studies of the key pathogenetic mechanisms of renal disease progression may also contribute to developing new approaches for targeted therapy.
format	article
author	Natalia Chebotareva Anatoliy Vinogradov Valerie McDonnell Natalia V. Zakharova Maria I. Indeykina Sergey Moiseev Evgeny N. Nikolaev Alexey S. Kononikhin
author_facet	Natalia Chebotareva Anatoliy Vinogradov Valerie McDonnell Natalia V. Zakharova Maria I. Indeykina Sergey Moiseev Evgeny N. Nikolaev Alexey S. Kononikhin
author_sort	Natalia Chebotareva
title	Urinary Protein and Peptide Markers in Chronic Kidney Disease
title_short	Urinary Protein and Peptide Markers in Chronic Kidney Disease
title_full	Urinary Protein and Peptide Markers in Chronic Kidney Disease
title_fullStr	Urinary Protein and Peptide Markers in Chronic Kidney Disease
title_full_unstemmed	Urinary Protein and Peptide Markers in Chronic Kidney Disease
title_sort	urinary protein and peptide markers in chronic kidney disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a35a320973624eec8544317947641a25
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Urinary Protein and Peptide Markers in Chronic Kidney Disease

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