Histamine in cancer immunology and immunotherapy. Current status and new perspectives

Abstract Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in i...

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Autores principales:	María de la Paz Sarasola, Mónica A. Táquez Delgado, Melisa B. Nicoud, Vanina A. Medina
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	adaptive immunity anti‐tumor immunity breast cancer histamine receptors immunotherapy innate immunity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a35b5b0c681848ef9c7012a61da8b6be
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spelling	oai:doaj.org-article:a35b5b0c681848ef9c7012a61da8b6be2021-11-16T13:45:54ZHistamine in cancer immunology and immunotherapy. Current status and new perspectives2052-170710.1002/prp2.778https://doaj.org/article/a35b5b0c681848ef9c7012a61da8b6be2021-10-01T00:00:00Zhttps://doi.org/10.1002/prp2.778https://doaj.org/toc/2052-1707Abstract Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in impressive and durable responses but only in a fraction of patients. Thus, understanding the characteristics and profiles of immune cells in the tumor microenvironment (TME) is a necessary step to move forward in the design of new immunomodulatory strategies that can boost the immune system to fight cancer. Histamine produces a complex and fine‐tuned regulation of the phenotype and functions of the different immune cells, participating in multiple regulatory responses of the innate and adaptive immunity. Considering the important actions of histamine‐producing immune cells in the TME, in this review we first address the most important immunomodulatory roles of histamine and histamine receptors in the context of cancer development and progression. In addition, this review highlights the current progress and foundational developments in the field of cancer immunotherapy in combination with histamine and pharmacological compounds targeting histamine receptors.María de la Paz SarasolaMónica A. Táquez DelgadoMelisa B. NicoudVanina A. MedinaWileyarticleadaptive immunityanti‐tumor immunitybreast cancerhistamine receptorsimmunotherapyinnate immunityTherapeutics. PharmacologyRM1-950ENPharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adaptive immunity anti‐tumor immunity breast cancer histamine receptors immunotherapy innate immunity Therapeutics. Pharmacology RM1-950
spellingShingle	adaptive immunity anti‐tumor immunity breast cancer histamine receptors immunotherapy innate immunity Therapeutics. Pharmacology RM1-950 María de la Paz Sarasola Mónica A. Táquez Delgado Melisa B. Nicoud Vanina A. Medina Histamine in cancer immunology and immunotherapy. Current status and new perspectives
description	Abstract Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in impressive and durable responses but only in a fraction of patients. Thus, understanding the characteristics and profiles of immune cells in the tumor microenvironment (TME) is a necessary step to move forward in the design of new immunomodulatory strategies that can boost the immune system to fight cancer. Histamine produces a complex and fine‐tuned regulation of the phenotype and functions of the different immune cells, participating in multiple regulatory responses of the innate and adaptive immunity. Considering the important actions of histamine‐producing immune cells in the TME, in this review we first address the most important immunomodulatory roles of histamine and histamine receptors in the context of cancer development and progression. In addition, this review highlights the current progress and foundational developments in the field of cancer immunotherapy in combination with histamine and pharmacological compounds targeting histamine receptors.
format	article
author	María de la Paz Sarasola Mónica A. Táquez Delgado Melisa B. Nicoud Vanina A. Medina
author_facet	María de la Paz Sarasola Mónica A. Táquez Delgado Melisa B. Nicoud Vanina A. Medina
author_sort	María de la Paz Sarasola
title	Histamine in cancer immunology and immunotherapy. Current status and new perspectives
title_short	Histamine in cancer immunology and immunotherapy. Current status and new perspectives
title_full	Histamine in cancer immunology and immunotherapy. Current status and new perspectives
title_fullStr	Histamine in cancer immunology and immunotherapy. Current status and new perspectives
title_full_unstemmed	Histamine in cancer immunology and immunotherapy. Current status and new perspectives
title_sort	histamine in cancer immunology and immunotherapy. current status and new perspectives
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/a35b5b0c681848ef9c7012a61da8b6be
work_keys_str_mv	AT mariadelapazsarasola histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives AT monicaataquezdelgado histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives AT melisabnicoud histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives AT vaninaamedina histamineincancerimmunologyandimmunotherapycurrentstatusandnewperspectives
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Histamine in cancer immunology and immunotherapy. Current status and new perspectives

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