Lung microbiome alterations in NSCLC patients

Abstract Lung is colonized by a diverse array of microbes and the lung microbiota is profoundly involved in the development of respiratory diseases. There is little knowledge about the role of lung microbiota dysbiosis in lung cancer. In this study, we performed metagenomic sequencing on bronchoalve...

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Autores principales:	Leliang Zheng, Ruizheng Sun, Yinghong Zhu, Zheng Li, Xiaoling She, Xingxing Jian, Fenglei Yu, Xueyu Deng, Buqing Sai, Lujuan Wang, Wen Zhou, Minghua Wu, Guiyuan Li, Jingqun Tang, Wei Jia, Juanjuan Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a35db26d64f04a559d22532906d8f0e4
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spelling	oai:doaj.org-article:a35db26d64f04a559d22532906d8f0e42021-12-02T15:02:48ZLung microbiome alterations in NSCLC patients10.1038/s41598-021-91195-22045-2322https://doaj.org/article/a35db26d64f04a559d22532906d8f0e42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91195-2https://doaj.org/toc/2045-2322Abstract Lung is colonized by a diverse array of microbes and the lung microbiota is profoundly involved in the development of respiratory diseases. There is little knowledge about the role of lung microbiota dysbiosis in lung cancer. In this study, we performed metagenomic sequencing on bronchoalveolar lavage (BAL) from two different sampling methods in non-small cell lung cancer (NSCLC) patients and non-cancer controls. We found the obvious variation between bronchoscopy samples and lobectomy samples. Oral taxa can be found in both bronchoscopy and lobectomy samples and higher abundance of oral taxa can be found in bronchoscopy samples. Although the NSCLC patients had similar microbial communities with non-cancer controls, rare species such as Lactobacillus rossiae, Bacteroides pyogenes, Paenibacillus odorifer, Pseudomonas entomophila, Magnetospirillum gryphiswaldense, fungus Chaetomium globosum et al. showed obvious difference between NSCLC patients and non-cancer controls. Age-, gender-, and smoking-specific species and EGFR expression-related species in NSCLC patients were detected. There results implicated that different lung segments have differential lung microbiome composition. The oral taxa are found in the lobectomy samples suggesting that oral microbiota are the true members of lung microbiota, rather than contamination during bronchoscopy. Lung cancer does not obviously alter the global microbial composition, while rare species are altered more than common species. Certain microbes may be associated with lung cancer progression.Leliang ZhengRuizheng SunYinghong ZhuZheng LiXiaoling SheXingxing JianFenglei YuXueyu DengBuqing SaiLujuan WangWen ZhouMinghua WuGuiyuan LiJingqun TangWei JiaJuanjuan XiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leliang Zheng Ruizheng Sun Yinghong Zhu Zheng Li Xiaoling She Xingxing Jian Fenglei Yu Xueyu Deng Buqing Sai Lujuan Wang Wen Zhou Minghua Wu Guiyuan Li Jingqun Tang Wei Jia Juanjuan Xiang Lung microbiome alterations in NSCLC patients
description	Abstract Lung is colonized by a diverse array of microbes and the lung microbiota is profoundly involved in the development of respiratory diseases. There is little knowledge about the role of lung microbiota dysbiosis in lung cancer. In this study, we performed metagenomic sequencing on bronchoalveolar lavage (BAL) from two different sampling methods in non-small cell lung cancer (NSCLC) patients and non-cancer controls. We found the obvious variation between bronchoscopy samples and lobectomy samples. Oral taxa can be found in both bronchoscopy and lobectomy samples and higher abundance of oral taxa can be found in bronchoscopy samples. Although the NSCLC patients had similar microbial communities with non-cancer controls, rare species such as Lactobacillus rossiae, Bacteroides pyogenes, Paenibacillus odorifer, Pseudomonas entomophila, Magnetospirillum gryphiswaldense, fungus Chaetomium globosum et al. showed obvious difference between NSCLC patients and non-cancer controls. Age-, gender-, and smoking-specific species and EGFR expression-related species in NSCLC patients were detected. There results implicated that different lung segments have differential lung microbiome composition. The oral taxa are found in the lobectomy samples suggesting that oral microbiota are the true members of lung microbiota, rather than contamination during bronchoscopy. Lung cancer does not obviously alter the global microbial composition, while rare species are altered more than common species. Certain microbes may be associated with lung cancer progression.
format	article
author	Leliang Zheng Ruizheng Sun Yinghong Zhu Zheng Li Xiaoling She Xingxing Jian Fenglei Yu Xueyu Deng Buqing Sai Lujuan Wang Wen Zhou Minghua Wu Guiyuan Li Jingqun Tang Wei Jia Juanjuan Xiang
author_facet	Leliang Zheng Ruizheng Sun Yinghong Zhu Zheng Li Xiaoling She Xingxing Jian Fenglei Yu Xueyu Deng Buqing Sai Lujuan Wang Wen Zhou Minghua Wu Guiyuan Li Jingqun Tang Wei Jia Juanjuan Xiang
author_sort	Leliang Zheng
title	Lung microbiome alterations in NSCLC patients
title_short	Lung microbiome alterations in NSCLC patients
title_full	Lung microbiome alterations in NSCLC patients
title_fullStr	Lung microbiome alterations in NSCLC patients
title_full_unstemmed	Lung microbiome alterations in NSCLC patients
title_sort	lung microbiome alterations in nsclc patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a35db26d64f04a559d22532906d8f0e4
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Lung microbiome alterations in NSCLC patients

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