Dose–Response Relationship Between BMI and Hyperuricemia
Lu Yang,1 Zhen’an He,2 Xuan Gu,3 Hao Cheng,4 Lin Li5 1Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital City, Hangzhou, Zhejiang Province, People’s Republic of China; 2Shaanxi Institute of Medical Device Quality Supervision and Inspection, Xi’an City, Shaanxi Province, People’s Republ...
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Dove Medical Press
2021
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oai:doaj.org-article:a35de51f27294f61a27b7e4c93efbd1f2021-11-11T18:22:26ZDose–Response Relationship Between BMI and Hyperuricemia1178-7074https://doaj.org/article/a35de51f27294f61a27b7e4c93efbd1f2021-11-01T00:00:00Zhttps://www.dovepress.com/doseresponse-relationship-between-bmi-and-hyperuricemia-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Lu Yang,1 Zhen’an He,2 Xuan Gu,3 Hao Cheng,4 Lin Li5 1Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital City, Hangzhou, Zhejiang Province, People’s Republic of China; 2Shaanxi Institute of Medical Device Quality Supervision and Inspection, Xi’an City, Shaanxi Province, People’s Republic of China; 3Xi’an Hospital of Civil Aviation, Xi’an City, Shaanxi Province, People’s Republic of China; 4Department of Ultrasonography, Shaanxi Cancer Hospital Affiliated to Xi’an Jiaotong University, Xi’an City, Shaanxi Province, People’s Republic of China; 5Shaanxi Cancer Hospital Affiliated to Xi’an Jiaotong University, Xi’an City, Shaanxi Province, People’s Republic of ChinaCorrespondence: Hao Cheng; Lin Li Email uschenghao@163.com; lloyd_115599@sina.comObjective: The purpose of the current study is to explore the demographic characteristics of hyperuricemia in China.Study Design: The cross-sectional study was conducted, and the CHARLS dataset in 2011 was used.Methods: Logistic regression model was used to assess the association between BMI and hyperuricemia. We also used restricted cubic spline with three knots to assess the dose–response relationship. To investigate the differences in dose–response relationships in various groups, stratification analysis was conducted.Results: Of the 9408 middle and older participants, those who were overweight or obese had higher risk for hyperuricemia (OR=1.26, 95% CI=1.01– 1.57; OR=1.90, 95% CI=1.46– 2.47). In the subgroup, the effect of obesity on hyperuricemia was robust in varying gender and age. However, among overweight group, those with being male and aged over 60 years had higher risk for hyperuricemia (male: OR=1.42, 95% CI=1.07– 1.90; over 60 years: OR=1.28, 95% CI=1.03– 1.60). A dose-response relationship was examined between BMI and the risk of hyperuricemia. The result showed that the odds ratio of hyperuricemia and BMI displayed U-shaped nonlinear relationship (Ptrend< 0.001, non-linear P< 0.001).Conclusion: The association between BMI and hyperuricemia showed positive relationship. Specifically, the group with male and age over 60 years had higher risk of hyperuricemia along with increased weight.Keywords: body mass index, hyperuricemia, CHARLS, middle and older peopleYang LHe ZGu XCheng HLi LDove Medical Pressarticlebody mass indexhyperuricemiacharlsmiddle and older peopleMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8065-8071 (2021) |
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DOAJ |
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body mass index hyperuricemia charls middle and older people Medicine (General) R5-920 |
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body mass index hyperuricemia charls middle and older people Medicine (General) R5-920 Yang L He Z Gu X Cheng H Li L Dose–Response Relationship Between BMI and Hyperuricemia |
| description |
Lu Yang,1 Zhen’an He,2 Xuan Gu,3 Hao Cheng,4 Lin Li5 1Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital City, Hangzhou, Zhejiang Province, People’s Republic of China; 2Shaanxi Institute of Medical Device Quality Supervision and Inspection, Xi’an City, Shaanxi Province, People’s Republic of China; 3Xi’an Hospital of Civil Aviation, Xi’an City, Shaanxi Province, People’s Republic of China; 4Department of Ultrasonography, Shaanxi Cancer Hospital Affiliated to Xi’an Jiaotong University, Xi’an City, Shaanxi Province, People’s Republic of China; 5Shaanxi Cancer Hospital Affiliated to Xi’an Jiaotong University, Xi’an City, Shaanxi Province, People’s Republic of ChinaCorrespondence: Hao Cheng; Lin Li Email uschenghao@163.com; lloyd_115599@sina.comObjective: The purpose of the current study is to explore the demographic characteristics of hyperuricemia in China.Study Design: The cross-sectional study was conducted, and the CHARLS dataset in 2011 was used.Methods: Logistic regression model was used to assess the association between BMI and hyperuricemia. We also used restricted cubic spline with three knots to assess the dose–response relationship. To investigate the differences in dose–response relationships in various groups, stratification analysis was conducted.Results: Of the 9408 middle and older participants, those who were overweight or obese had higher risk for hyperuricemia (OR=1.26, 95% CI=1.01– 1.57; OR=1.90, 95% CI=1.46– 2.47). In the subgroup, the effect of obesity on hyperuricemia was robust in varying gender and age. However, among overweight group, those with being male and aged over 60 years had higher risk for hyperuricemia (male: OR=1.42, 95% CI=1.07– 1.90; over 60 years: OR=1.28, 95% CI=1.03– 1.60). A dose-response relationship was examined between BMI and the risk of hyperuricemia. The result showed that the odds ratio of hyperuricemia and BMI displayed U-shaped nonlinear relationship (Ptrend< 0.001, non-linear P< 0.001).Conclusion: The association between BMI and hyperuricemia showed positive relationship. Specifically, the group with male and age over 60 years had higher risk of hyperuricemia along with increased weight.Keywords: body mass index, hyperuricemia, CHARLS, middle and older people |
| format |
article |
| author |
Yang L He Z Gu X Cheng H Li L |
| author_facet |
Yang L He Z Gu X Cheng H Li L |
| author_sort |
Yang L |
| title |
Dose–Response Relationship Between BMI and Hyperuricemia |
| title_short |
Dose–Response Relationship Between BMI and Hyperuricemia |
| title_full |
Dose–Response Relationship Between BMI and Hyperuricemia |
| title_fullStr |
Dose–Response Relationship Between BMI and Hyperuricemia |
| title_full_unstemmed |
Dose–Response Relationship Between BMI and Hyperuricemia |
| title_sort |
dose–response relationship between bmi and hyperuricemia |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/a35de51f27294f61a27b7e4c93efbd1f |
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