Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
Excitatory glycine GluN1/GluN3A receptors are atypical NMDARs that have been difficult to study. Here the authors identify new properties of these receptors, including potentiation by the GluN1 antagonist CGP-78608 that allows detection of functional GluN1/GluN3A receptors in the juvenile brain.
Guardado en:
Autores principales: | Teddy Grand, Sarah Abi Gerges, Mélissa David, Marco A. Diana, Pierre Paoletti |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a35def0fe6364fabae0dd780be3a84b4 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
GluN2A and GluN2B NMDA receptors use distinct allosteric routes
por: Meilin Tian, et al.
Publicado: (2021) -
Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
por: Kristyna Skrenkova, et al.
Publicado: (2019) -
A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors
por: Divyan A. Chopra, et al.
Publicado: (2017) -
Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
por: María J Conde-Dusman, et al.
Publicado: (2021) -
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
por: Jue Xiang Wang, et al.
Publicado: (2020)