Synthetic spike-in standards improve run-specific systematic error analysis for DNA and RNA sequencing.

While the importance of random sequencing errors decreases at higher DNA or RNA sequencing depths, systematic sequencing errors (SSEs) dominate at high sequencing depths and can be difficult to distinguish from biological variants. These SSEs can cause base quality scores to underestimate the probab...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Justin M Zook, Daniel Samarov, Jennifer McDaniel, Shurjo K Sen, Marc Salit
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
R
Q
Acceso en línea:https://doaj.org/article/a35ecb62c8ca4ec2a8ace6b4145a01de
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!