Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer
Resistance to Trastuzumab in HER2 gastric cancer patients remains a clinical challenge. In this study, the authors demonstrate that HER2 promotes tumorigenesis in gastric cancer by regulating mitotic progression through a Shc1-SHCBP1-PLK1-MISP axis and they identify a compound, TFBG, able to disrupt...
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Nature Portfolio
2021
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oai:doaj.org-article:a36742197f8f4e5f8d941649431f83ec2021-12-02T15:43:06ZHyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer10.1038/s41467-021-23053-82041-1723https://doaj.org/article/a36742197f8f4e5f8d941649431f83ec2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23053-8https://doaj.org/toc/2041-1723Resistance to Trastuzumab in HER2 gastric cancer patients remains a clinical challenge. In this study, the authors demonstrate that HER2 promotes tumorigenesis in gastric cancer by regulating mitotic progression through a Shc1-SHCBP1-PLK1-MISP axis and they identify a compound, TFBG, able to disrupt SHCBP1/PLK1 interaction and to synergize with trastuzumab.Wengui ShiGengyuan ZhangZhijian MaLianshun LiMiaomiao LiuLong QinZeyuan YuLei ZhaoYang LiuXue ZhangJunjie QinHuili YeXiangyan JiangHuinian ZhouHui SunZuoyi JiaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Wengui Shi Gengyuan Zhang Zhijian Ma Lianshun Li Miaomiao Liu Long Qin Zeyuan Yu Lei Zhao Yang Liu Xue Zhang Junjie Qin Huili Ye Xiangyan Jiang Huinian Zhou Hui Sun Zuoyi Jiao Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer |
| description |
Resistance to Trastuzumab in HER2 gastric cancer patients remains a clinical challenge. In this study, the authors demonstrate that HER2 promotes tumorigenesis in gastric cancer by regulating mitotic progression through a Shc1-SHCBP1-PLK1-MISP axis and they identify a compound, TFBG, able to disrupt SHCBP1/PLK1 interaction and to synergize with trastuzumab. |
| format |
article |
| author |
Wengui Shi Gengyuan Zhang Zhijian Ma Lianshun Li Miaomiao Liu Long Qin Zeyuan Yu Lei Zhao Yang Liu Xue Zhang Junjie Qin Huili Ye Xiangyan Jiang Huinian Zhou Hui Sun Zuoyi Jiao |
| author_facet |
Wengui Shi Gengyuan Zhang Zhijian Ma Lianshun Li Miaomiao Liu Long Qin Zeyuan Yu Lei Zhao Yang Liu Xue Zhang Junjie Qin Huili Ye Xiangyan Jiang Huinian Zhou Hui Sun Zuoyi Jiao |
| author_sort |
Wengui Shi |
| title |
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer |
| title_short |
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer |
| title_full |
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer |
| title_fullStr |
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer |
| title_full_unstemmed |
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer |
| title_sort |
hyperactivation of her2-shcbp1-plk1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a36742197f8f4e5f8d941649431f83ec |
| work_keys_str_mv |
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| _version_ |
1718385825780072448 |