Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity

Nancy Abdel Salam Gomaa,1 Youssef AH Helmy,2 Sara Maher,2 Dina Hassanein,2 Asmaa Shuaib,2 Ahmed I Hegazy,2 Aliaa A Ali1 1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Ali...

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Autores principales:	Abdel Salam Gomaa N, Helmy YAH, Maher S, Hassanein D, Shuaib A, Hegazy AI, Ali AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	aggressive posterior retinopathy of prematurity caffeine dopamine preterm neonate small for gestational age Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a36a03355fdf452aaaf872615a19b92b
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spelling	oai:doaj.org-article:a36a03355fdf452aaaf872615a19b92b2021-12-02T14:39:27ZClinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity1177-5483https://doaj.org/article/a36a03355fdf452aaaf872615a19b92b2021-06-01T00:00:00Zhttps://www.dovepress.com/clinical-characteristics-of-preterm-neonates-with-aggressive-posterior-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Nancy Abdel Salam Gomaa,1 Youssef AH Helmy,2 Sara Maher,2 Dina Hassanein,2 Asmaa Shuaib,2 Ahmed I Hegazy,2 Aliaa A Ali1 1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Aliaa A AliDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo University Specialized Pediatric Hospital, 1 Ali Basha Ibrahim Street, Giza, Cairo, 11562, EgyptTel +201001115611Email draliaaadel@yahoo.comPurpose: We aimed to identify the risk factors that may predispose preterm neonates to develop aggressive posterior retinopathy of prematurity (APROP).Methods: This retrospective case control study included 16 infants with APROP in zone 1 or posterior zone 2. Thirty-four gestational age and birth weight-matched controls with stage 2 or less ROP were included. We reviewed medical records on infant birth and postnatal characteristics.Results: Patients who developed APROP had a significantly longer duration of caffeine therapy, were significantly more likely to be small for gestational age (SGA), and were more likely to have a positive blood culture than patients who developed less severe ROP. Patients with APROP who required retreatment had received inotropes for a longer duration of time, had received more plasma transfusions, were more likely to have IVH, and had a greater decrease in the serum hemoglobin during hospitalization.Conclusion: Being SGA, receiving caffeine for a longer duration, and having culture-proven sepsis were associated with APROP. IVH, a low serum hemoglobin, the need for more plasma transfusions, and a longer duration of inotropes were associated with APROP which required retreatment.Keywords: aggressive posterior retinopathy of prematurity, caffeine, dopamine, preterm neonate, small for gestational ageAbdel Salam Gomaa NHelmy YAHMaher SHassanein DShuaib AHegazy AIAli AADove Medical Pressarticleaggressive posterior retinopathy of prematuritycaffeinedopaminepreterm neonatesmall for gestational ageOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2263-2277 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aggressive posterior retinopathy of prematurity caffeine dopamine preterm neonate small for gestational age Ophthalmology RE1-994
spellingShingle	aggressive posterior retinopathy of prematurity caffeine dopamine preterm neonate small for gestational age Ophthalmology RE1-994 Abdel Salam Gomaa N Helmy YAH Maher S Hassanein D Shuaib A Hegazy AI Ali AA Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity
description	Nancy Abdel Salam Gomaa,1 Youssef AH Helmy,2 Sara Maher,2 Dina Hassanein,2 Asmaa Shuaib,2 Ahmed I Hegazy,2 Aliaa A Ali1 1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Aliaa A AliDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo University Specialized Pediatric Hospital, 1 Ali Basha Ibrahim Street, Giza, Cairo, 11562, EgyptTel +201001115611Email draliaaadel@yahoo.comPurpose: We aimed to identify the risk factors that may predispose preterm neonates to develop aggressive posterior retinopathy of prematurity (APROP).Methods: This retrospective case control study included 16 infants with APROP in zone 1 or posterior zone 2. Thirty-four gestational age and birth weight-matched controls with stage 2 or less ROP were included. We reviewed medical records on infant birth and postnatal characteristics.Results: Patients who developed APROP had a significantly longer duration of caffeine therapy, were significantly more likely to be small for gestational age (SGA), and were more likely to have a positive blood culture than patients who developed less severe ROP. Patients with APROP who required retreatment had received inotropes for a longer duration of time, had received more plasma transfusions, were more likely to have IVH, and had a greater decrease in the serum hemoglobin during hospitalization.Conclusion: Being SGA, receiving caffeine for a longer duration, and having culture-proven sepsis were associated with APROP. IVH, a low serum hemoglobin, the need for more plasma transfusions, and a longer duration of inotropes were associated with APROP which required retreatment.Keywords: aggressive posterior retinopathy of prematurity, caffeine, dopamine, preterm neonate, small for gestational age
format	article
author	Abdel Salam Gomaa N Helmy YAH Maher S Hassanein D Shuaib A Hegazy AI Ali AA
author_facet	Abdel Salam Gomaa N Helmy YAH Maher S Hassanein D Shuaib A Hegazy AI Ali AA
author_sort	Abdel Salam Gomaa N
title	Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity
title_short	Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity
title_full	Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity
title_fullStr	Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity
title_full_unstemmed	Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity
title_sort	clinical characteristics of preterm neonates with aggressive posterior retinopathy of prematurity
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a36a03355fdf452aaaf872615a19b92b
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_version_	1718390608704307200

Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity

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