Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism

Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detecta...

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Autores principales:	Rianne E. van Outersterp, Sam J. Moons, Udo F. H. Engelke, Herman Bentlage, Tessa M. A. Peters, Arno van Rooij, Marleen C. D. G. Huigen, Siebolt de Boer, Ed van der Heeft, Leo A. J. Kluijtmans, Clara D. M. van Karnebeek, Ron A. Wevers, Giel Berden, Jos Oomens, Thomas J. Boltje, Karlien L. M. Coene, Jonathan Martens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a3702831608e413ca3c44c8e50fdc0d3
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spelling	oai:doaj.org-article:a3702831608e413ca3c44c8e50fdc0d32021-12-02T17:05:09ZAmadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism10.1038/s42003-021-01909-52399-3642https://doaj.org/article/a3702831608e413ca3c44c8e50fdc0d32021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01909-5https://doaj.org/toc/2399-3642Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detectable in blood samples from unaffected individuals, and may therefore represent disease biomarkers.Rianne E. van OutersterpSam J. MoonsUdo F. H. EngelkeHerman BentlageTessa M. A. PetersArno van RooijMarleen C. D. G. HuigenSiebolt de BoerEd van der HeeftLeo A. J. KluijtmansClara D. M. van KarnebeekRon A. WeversGiel BerdenJos OomensThomas J. BoltjeKarlien L. M. CoeneJonathan MartensNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Rianne E. van Outersterp Sam J. Moons Udo F. H. Engelke Herman Bentlage Tessa M. A. Peters Arno van Rooij Marleen C. D. G. Huigen Siebolt de Boer Ed van der Heeft Leo A. J. Kluijtmans Clara D. M. van Karnebeek Ron A. Wevers Giel Berden Jos Oomens Thomas J. Boltje Karlien L. M. Coene Jonathan Martens Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
description	Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detectable in blood samples from unaffected individuals, and may therefore represent disease biomarkers.
format	article
author	Rianne E. van Outersterp Sam J. Moons Udo F. H. Engelke Herman Bentlage Tessa M. A. Peters Arno van Rooij Marleen C. D. G. Huigen Siebolt de Boer Ed van der Heeft Leo A. J. Kluijtmans Clara D. M. van Karnebeek Ron A. Wevers Giel Berden Jos Oomens Thomas J. Boltje Karlien L. M. Coene Jonathan Martens
author_facet	Rianne E. van Outersterp Sam J. Moons Udo F. H. Engelke Herman Bentlage Tessa M. A. Peters Arno van Rooij Marleen C. D. G. Huigen Siebolt de Boer Ed van der Heeft Leo A. J. Kluijtmans Clara D. M. van Karnebeek Ron A. Wevers Giel Berden Jos Oomens Thomas J. Boltje Karlien L. M. Coene Jonathan Martens
author_sort	Rianne E. van Outersterp
title	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_short	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_full	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_fullStr	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_full_unstemmed	Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
title_sort	amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3702831608e413ca3c44c8e50fdc0d3
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Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism

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