Integrated genetic and pharmacologic interrogation of rare cancers

Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 a...

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Autores principales:	Andrew L. Hong, Yuen-Yi Tseng, Glenn S. Cowley, Oliver Jonas, Jaime H. Cheah, Bryan D. Kynnap, Mihir B. Doshi, Coyin Oh, Stephanie C. Meyer, Alanna J. Church, Shubhroz Gill, Craig M. Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V. Kryukov, Paul A. Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D. Crompton, Alykhan F. Shamji, Carlos Rodriguez-Galindo, Katherine A. Janeway, Charles W. M. Roberts, Kimberly Stegmaier, Paul van Hummelen, Michael J. Cima, Robert S. Langer, Levi A. Garraway, Stuart L. Schreiber, David E. Root, William C. Hahn, Jesse S. Boehm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a374f09a5d1640b381b40c1ebaec01db
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spelling	oai:doaj.org-article:a374f09a5d1640b381b40c1ebaec01db2021-12-02T15:34:30ZIntegrated genetic and pharmacologic interrogation of rare cancers10.1038/ncomms119872041-1723https://doaj.org/article/a374f09a5d1640b381b40c1ebaec01db2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11987https://doaj.org/toc/2041-1723Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.Andrew L. HongYuen-Yi TsengGlenn S. CowleyOliver JonasJaime H. CheahBryan D. KynnapMihir B. DoshiCoyin OhStephanie C. MeyerAlanna J. ChurchShubhroz GillCraig M. BielskiPaula KeskulaAlma ImamovicSara HowellGregory V. KryukovPaul A. ClemonsAviad TsherniakFrancisca VazquezBrian D. CromptonAlykhan F. ShamjiCarlos Rodriguez-GalindoKatherine A. JanewayCharles W. M. RobertsKimberly StegmaierPaul van HummelenMichael J. CimaRobert S. LangerLevi A. GarrawayStuart L. SchreiberDavid E. RootWilliam C. HahnJesse S. BoehmNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew L. Hong Yuen-Yi Tseng Glenn S. Cowley Oliver Jonas Jaime H. Cheah Bryan D. Kynnap Mihir B. Doshi Coyin Oh Stephanie C. Meyer Alanna J. Church Shubhroz Gill Craig M. Bielski Paula Keskula Alma Imamovic Sara Howell Gregory V. Kryukov Paul A. Clemons Aviad Tsherniak Francisca Vazquez Brian D. Crompton Alykhan F. Shamji Carlos Rodriguez-Galindo Katherine A. Janeway Charles W. M. Roberts Kimberly Stegmaier Paul van Hummelen Michael J. Cima Robert S. Langer Levi A. Garraway Stuart L. Schreiber David E. Root William C. Hahn Jesse S. Boehm Integrated genetic and pharmacologic interrogation of rare cancers
description	Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.
format	article
author	Andrew L. Hong Yuen-Yi Tseng Glenn S. Cowley Oliver Jonas Jaime H. Cheah Bryan D. Kynnap Mihir B. Doshi Coyin Oh Stephanie C. Meyer Alanna J. Church Shubhroz Gill Craig M. Bielski Paula Keskula Alma Imamovic Sara Howell Gregory V. Kryukov Paul A. Clemons Aviad Tsherniak Francisca Vazquez Brian D. Crompton Alykhan F. Shamji Carlos Rodriguez-Galindo Katherine A. Janeway Charles W. M. Roberts Kimberly Stegmaier Paul van Hummelen Michael J. Cima Robert S. Langer Levi A. Garraway Stuart L. Schreiber David E. Root William C. Hahn Jesse S. Boehm
author_facet	Andrew L. Hong Yuen-Yi Tseng Glenn S. Cowley Oliver Jonas Jaime H. Cheah Bryan D. Kynnap Mihir B. Doshi Coyin Oh Stephanie C. Meyer Alanna J. Church Shubhroz Gill Craig M. Bielski Paula Keskula Alma Imamovic Sara Howell Gregory V. Kryukov Paul A. Clemons Aviad Tsherniak Francisca Vazquez Brian D. Crompton Alykhan F. Shamji Carlos Rodriguez-Galindo Katherine A. Janeway Charles W. M. Roberts Kimberly Stegmaier Paul van Hummelen Michael J. Cima Robert S. Langer Levi A. Garraway Stuart L. Schreiber David E. Root William C. Hahn Jesse S. Boehm
author_sort	Andrew L. Hong
title	Integrated genetic and pharmacologic interrogation of rare cancers
title_short	Integrated genetic and pharmacologic interrogation of rare cancers
title_full	Integrated genetic and pharmacologic interrogation of rare cancers
title_fullStr	Integrated genetic and pharmacologic interrogation of rare cancers
title_full_unstemmed	Integrated genetic and pharmacologic interrogation of rare cancers
title_sort	integrated genetic and pharmacologic interrogation of rare cancers
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a374f09a5d1640b381b40c1ebaec01db
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Integrated genetic and pharmacologic interrogation of rare cancers

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