Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate them via the hepatobiliary route.

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Detalles Bibliográficos
Autores principales:	Xiaodong Xie, Huifang Nie, Yu Zhou, Shu Lian, Hao Mei, Yusheng Lu, Haiyan Dong, Fengqiao Li, Tao Li, Bifei Li, Jie Wang, Min Lin, Chaihung Wang, Jingwei Shao, Yu Gao, Jianming Chen, Fangwei Xie, Lee Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a37684587e3f4184b798b112c3849bf7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a37684587e3f4184b798b112c3849bf72021-12-02T17:02:10ZEliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles10.1038/s41467-019-13316-w2041-1723https://doaj.org/article/a37684587e3f4184b798b112c3849bf72019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13316-whttps://doaj.org/toc/2041-1723Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate them via the hepatobiliary route.Xiaodong XieHuifang NieYu ZhouShu LianHao MeiYusheng LuHaiyan DongFengqiao LiTao LiBifei LiJie WangMin LinChaihung WangJingwei ShaoYu GaoJianming ChenFangwei XieLee JiaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaodong Xie Huifang Nie Yu Zhou Shu Lian Hao Mei Yusheng Lu Haiyan Dong Fengqiao Li Tao Li Bifei Li Jie Wang Min Lin Chaihung Wang Jingwei Shao Yu Gao Jianming Chen Fangwei Xie Lee Jia Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
description	Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate them via the hepatobiliary route.
format	article
author	Xiaodong Xie Huifang Nie Yu Zhou Shu Lian Hao Mei Yusheng Lu Haiyan Dong Fengqiao Li Tao Li Bifei Li Jie Wang Min Lin Chaihung Wang Jingwei Shao Yu Gao Jianming Chen Fangwei Xie Lee Jia
author_facet	Xiaodong Xie Huifang Nie Yu Zhou Shu Lian Hao Mei Yusheng Lu Haiyan Dong Fengqiao Li Tao Li Bifei Li Jie Wang Min Lin Chaihung Wang Jingwei Shao Yu Gao Jianming Chen Fangwei Xie Lee Jia
author_sort	Xiaodong Xie
title	Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
title_short	Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
title_full	Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
title_fullStr	Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
title_full_unstemmed	Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
title_sort	eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a37684587e3f4184b798b112c3849bf7
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Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

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