A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

Abstract CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX). To enrich CRISPR/Cas9-edited cells, we improved a dual-re...

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Autores principales: Wen-Hsin Liu, Kerstin Völse, Daniela Senft, Irmela Jeremias
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a377dc79c39245ce948428dc257d1833
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