Deletion of <italic toggle="yes">nuoG</italic> from the Vaccine Candidate <named-content content-type="genus-species">Mycobacterium bovis</named-content> BCG Δ<italic toggle="yes">ureC</italic>::<italic toggle="yes">hly</italic> Improves Protection against Tuberculosis

Deletion of <italic toggle="yes">nuoG</italic> from the Vaccine Candidate <named-content content-type="genus-species">Mycobacterium bovis</named-content> BCG Δ<italic toggle="yes">ureC</italic>::<italic toggle="yes">hly</italic> Improves Protection against Tuberculosis

ABSTRACT The current tuberculosis (TB) vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), provides insufficient protection against pulmonary TB. Previously, we generated a listeriolysin-expressing recombinant BCG strain, which to date has successfully completed phase I and phase IIa clinic...

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Autores principales: Martin Gengenbacher, Natalie Nieuwenhuizen, Alexis Vogelzang, Haipeng Liu, Peggy Kaiser, Stefanie Schuerer, Doris Lazar, Ina Wagner, Hans-Joachim Mollenkopf, Stefan H. E. Kaufmann
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/a3795285567a431ba72958df4832df9e
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