Neuromodulation in eating disorders and obesity: a promising way of treatment?

Ignacio Jáuregui-Lobera,1 José V Martínez-Quiñones2 1Department of Molecular Biology and Biochemical Engineering, University of Pablo de Olavide of Seville, Seville, Spain; 2Department of Neurosurgery, Mutua de Accidentes de Zaragoza (Servicio de Neurocir...

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Autores principales:	Jáuregui-Lobera I, Martínez-Quiñones JV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	deep brain stimulation transcranial direct current stimulation transcranial magnetic stimulation anorexia nervosa bulimia nervosa obesity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a37af94280554b56bdf20f901b59f6e4
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spelling	oai:doaj.org-article:a37af94280554b56bdf20f901b59f6e42021-12-02T06:00:11ZNeuromodulation in eating disorders and obesity: a promising way of treatment?1178-2021https://doaj.org/article/a37af94280554b56bdf20f901b59f6e42018-10-01T00:00:00Zhttps://www.dovepress.com/neuromodulation-in-eating-disorders-and-obesity-a-promising-way-of-tre-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ignacio Jáuregui-Lobera,1 José V Martínez-Quiñones2 1Department of Molecular Biology and Biochemical Engineering, University of Pablo de Olavide of Seville, Seville, Spain; 2Department of Neurosurgery, Mutua de Accidentes de Zaragoza (Servicio de Neurocirugía), Zaragoza, Spain Abstract: Neuromodulation can affect the functioning of the central nervous system (CNS), and emotional/eating behavior is an exciting facet of that functioning. Therefore, it would be possible to offer an alternative (or complement) treatment to psychotropic medications and different psychological and nutritional approaches to both eating disorders (EDs) and obesity. Although there are a number of publications in these areas, a systematic review has not been conducted to date. Abstracts, letters, conference reports, dissertations, and reviews were excluded. Clinical trials and controlled human clinical trials were filtered and included in this study. Articles included were based on the population suffering from anorexia nervosa, bulimia nervosa, binge ED, overweight, and obesity. No restrictions were placed on the sample size. Only trials investigating the effect of neuromodulation by means of deep brain stimulation (DBS), transcranial direct current stimulation (tDCS), and transcranial magnetic stimulation (TMS) were included. The following databases were used to conduct the search: MEDLINE/PubMed, PsycINFO, PsycArticles, and Cochrane (Search Trials, CENTRAL). Study selection was performed following the PRISMA process (PRISMA 2009 Checklist). The total number of participants in all the trials was 562 (DBS, 25; tDCS, 138; TMS, 399; range, 3–90; median, 23.5). As a result, 50% of the studies had samples of between 14 and 38 participants. Neuromodulation in ED seems to have certain clinical potential, and therefore, this is a promising area for further research. Developments in ED neuromodulation will be linked to neuroimaging to identify potential stimulation targets and possible biomarkers of treatment response. To date, TMS and/or direct current stimulation (DCS) is not the first-line treatment yet, but it could become a preferred option of treatment in the future. Further studies should avoid small sample sizes and the use of different methodologies. Currently, neuromodulation techniques are in the experimental phase, and they are not an evidence-based treatment for ED. Keywords: deep brain stimulation, transcranial direct current stimulation, transcranial magnetic stimulation, anorexia nervosa, bulimia nervosa, obesity Jáuregui-Lobera IMartínez-Quiñones JVDove Medical Pressarticledeep brain stimulationtranscranial direct current stimulationtranscranial magnetic stimulationanorexia nervosabulimia nervosaobesity.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2817-2835 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	deep brain stimulation transcranial direct current stimulation transcranial magnetic stimulation anorexia nervosa bulimia nervosa obesity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	deep brain stimulation transcranial direct current stimulation transcranial magnetic stimulation anorexia nervosa bulimia nervosa obesity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jáuregui-Lobera I Martínez-Quiñones JV Neuromodulation in eating disorders and obesity: a promising way of treatment?
description	Ignacio Jáuregui-Lobera,1 José V Martínez-Quiñones2 1Department of Molecular Biology and Biochemical Engineering, University of Pablo de Olavide of Seville, Seville, Spain; 2Department of Neurosurgery, Mutua de Accidentes de Zaragoza (Servicio de Neurocirugía), Zaragoza, Spain Abstract: Neuromodulation can affect the functioning of the central nervous system (CNS), and emotional/eating behavior is an exciting facet of that functioning. Therefore, it would be possible to offer an alternative (or complement) treatment to psychotropic medications and different psychological and nutritional approaches to both eating disorders (EDs) and obesity. Although there are a number of publications in these areas, a systematic review has not been conducted to date. Abstracts, letters, conference reports, dissertations, and reviews were excluded. Clinical trials and controlled human clinical trials were filtered and included in this study. Articles included were based on the population suffering from anorexia nervosa, bulimia nervosa, binge ED, overweight, and obesity. No restrictions were placed on the sample size. Only trials investigating the effect of neuromodulation by means of deep brain stimulation (DBS), transcranial direct current stimulation (tDCS), and transcranial magnetic stimulation (TMS) were included. The following databases were used to conduct the search: MEDLINE/PubMed, PsycINFO, PsycArticles, and Cochrane (Search Trials, CENTRAL). Study selection was performed following the PRISMA process (PRISMA 2009 Checklist). The total number of participants in all the trials was 562 (DBS, 25; tDCS, 138; TMS, 399; range, 3–90; median, 23.5). As a result, 50% of the studies had samples of between 14 and 38 participants. Neuromodulation in ED seems to have certain clinical potential, and therefore, this is a promising area for further research. Developments in ED neuromodulation will be linked to neuroimaging to identify potential stimulation targets and possible biomarkers of treatment response. To date, TMS and/or direct current stimulation (DCS) is not the first-line treatment yet, but it could become a preferred option of treatment in the future. Further studies should avoid small sample sizes and the use of different methodologies. Currently, neuromodulation techniques are in the experimental phase, and they are not an evidence-based treatment for ED. Keywords: deep brain stimulation, transcranial direct current stimulation, transcranial magnetic stimulation, anorexia nervosa, bulimia nervosa, obesity
format	article
author	Jáuregui-Lobera I Martínez-Quiñones JV
author_facet	Jáuregui-Lobera I Martínez-Quiñones JV
author_sort	Jáuregui-Lobera I
title	Neuromodulation in eating disorders and obesity: a promising way of treatment?
title_short	Neuromodulation in eating disorders and obesity: a promising way of treatment?
title_full	Neuromodulation in eating disorders and obesity: a promising way of treatment?
title_fullStr	Neuromodulation in eating disorders and obesity: a promising way of treatment?
title_full_unstemmed	Neuromodulation in eating disorders and obesity: a promising way of treatment?
title_sort	neuromodulation in eating disorders and obesity: a promising way of treatment?
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a37af94280554b56bdf20f901b59f6e4
work_keys_str_mv	AT jaureguiloberai neuromodulationineatingdisordersandobesityapromisingwayoftreatment AT martinezquinonesjv neuromodulationineatingdisordersandobesityapromisingwayoftreatment
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Neuromodulation in eating disorders and obesity: a promising way of treatment?

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