Actinomycin V Induces Apoptosis Associated with Mitochondrial and PI3K/AKT Pathways in Human CRC Cells

Actinomycin V Induces Apoptosis Associated with Mitochondrial and PI3K/AKT Pathways in Human CRC Cells

Actinomycin (Act) V, an analogue of Act D, presented stronger antitumor activity and less hepatorenal toxicity than Act D in our previous studies, which is worthy of further investigation. We hereby report that Act V induces apoptosis via mitochondrial and PI3K/AKT pathways in colorectal cancer (CRC...

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Autores principales: Shiqing Jiang, E Zhang, Hang Ruan, Jiahui Ma, Xingming Zhao, Yaoyao Zhu, Xiaoyu Xie, Ningning Han, Jianjiang Li, Hao Zhang, Weidong Xie, Xia Li
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
Act V
CRC
PI3K/AKT
apoptosis
mitochondrial
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/a3811ae233a94ee9961261caca143caa
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