The association between structure-function relationships and cognitive impairment in elderly glaucoma patients

Abstract Accurate measurement of visual field (VF) is important in accessing glaucoma, however this may not be achieved in patients with dementia or mild cognitive impairment (CI). We investigated the association between CI and structure-function relationships in elderly glaucoma patients. The study...

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Autores principales:	Megumi Honjo, Jiro Numaga, Tadashi Hara, Ryo Asaoka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a382c676c0f946e986f79d584883dcb8
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spelling	oai:doaj.org-article:a382c676c0f946e986f79d584883dcb82021-12-02T15:06:27ZThe association between structure-function relationships and cognitive impairment in elderly glaucoma patients10.1038/s41598-017-07714-72045-2322https://doaj.org/article/a382c676c0f946e986f79d584883dcb82017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07714-7https://doaj.org/toc/2045-2322Abstract Accurate measurement of visual field (VF) is important in accessing glaucoma, however this may not be achieved in patients with dementia or mild cognitive impairment (CI). We investigated the association between CI and structure-function relationships in elderly glaucoma patients. The study included 94 eyes of 51 glaucoma patients aged ≥75 years with no diagnoses of dementia. CI was assessed using the Mini Mental State Examination (MMSE). Using the leave-one-out cross-validation, the mean deviation (MD) of the Humphrey 30-2 VF was predicted from measurements of optical coherence tomography, and the relationship between the squared prediction error and the MMSE score, together with age, fixation loss (FL), false positive (FP), and false negative (FN) percentages that were analyzed using the linear mixed model. A high prevalence of MCI or dementia was observed in the elderly population. The squared prediction error value of the MD was 17.0 ± 21.1 (mean ± standard deviation). The squared prediction error increased with decreasing MMSE total score, but age, FL, FP, and FN were not related. Careful consideration is needed when interpreting the VF results of these patients, because VF can be over- or underestimated, as suggested by the decreased structure-function relationships.Megumi HonjoJiro NumagaTadashi HaraRyo AsaokaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Megumi Honjo Jiro Numaga Tadashi Hara Ryo Asaoka The association between structure-function relationships and cognitive impairment in elderly glaucoma patients
description	Abstract Accurate measurement of visual field (VF) is important in accessing glaucoma, however this may not be achieved in patients with dementia or mild cognitive impairment (CI). We investigated the association between CI and structure-function relationships in elderly glaucoma patients. The study included 94 eyes of 51 glaucoma patients aged ≥75 years with no diagnoses of dementia. CI was assessed using the Mini Mental State Examination (MMSE). Using the leave-one-out cross-validation, the mean deviation (MD) of the Humphrey 30-2 VF was predicted from measurements of optical coherence tomography, and the relationship between the squared prediction error and the MMSE score, together with age, fixation loss (FL), false positive (FP), and false negative (FN) percentages that were analyzed using the linear mixed model. A high prevalence of MCI or dementia was observed in the elderly population. The squared prediction error value of the MD was 17.0 ± 21.1 (mean ± standard deviation). The squared prediction error increased with decreasing MMSE total score, but age, FL, FP, and FN were not related. Careful consideration is needed when interpreting the VF results of these patients, because VF can be over- or underestimated, as suggested by the decreased structure-function relationships.
format	article
author	Megumi Honjo Jiro Numaga Tadashi Hara Ryo Asaoka
author_facet	Megumi Honjo Jiro Numaga Tadashi Hara Ryo Asaoka
author_sort	Megumi Honjo
title	The association between structure-function relationships and cognitive impairment in elderly glaucoma patients
title_short	The association between structure-function relationships and cognitive impairment in elderly glaucoma patients
title_full	The association between structure-function relationships and cognitive impairment in elderly glaucoma patients
title_fullStr	The association between structure-function relationships and cognitive impairment in elderly glaucoma patients
title_full_unstemmed	The association between structure-function relationships and cognitive impairment in elderly glaucoma patients
title_sort	association between structure-function relationships and cognitive impairment in elderly glaucoma patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a382c676c0f946e986f79d584883dcb8
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The association between structure-function relationships and cognitive impairment in elderly glaucoma patients

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