SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions

Abstract Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and sho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Luis Fernando Saraiva Macedo Timmers, Julia Vasconcellos Peixoto, Rodrigo Gay Ducati, José Fernando Ruggiero Bachega, Leandro de Mattos Pereira, Rafael Andrade Caceres, Fernanda Majolo, Guilherme Liberato da Silva, Débora Bublitz Anton, Odir Antônio Dellagostin, João Antônio Pegas Henriques, Léder Leal Xavier, Márcia Inês Goettert, Stefan Laufer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a38334c048754c499bd25a4e0e1ff844
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a38334c048754c499bd25a4e0e1ff844
record_format	dspace
spelling	oai:doaj.org-article:a38334c048754c499bd25a4e0e1ff8442021-12-02T17:52:42ZSARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions10.1038/s41598-021-91585-62045-2322https://doaj.org/article/a38334c048754c499bd25a4e0e1ff8442021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91585-6https://doaj.org/toc/2045-2322Abstract Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, contributing towards studies of selective structure-based drug discovery and vaccine development.Luis Fernando Saraiva Macedo TimmersJulia Vasconcellos PeixotoRodrigo Gay DucatiJosé Fernando Ruggiero BachegaLeandro de Mattos PereiraRafael Andrade CaceresFernanda MajoloGuilherme Liberato da SilvaDébora Bublitz AntonOdir Antônio DellagostinJoão Antônio Pegas HenriquesLéder Leal XavierMárcia Inês GoettertStefan LauferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luis Fernando Saraiva Macedo Timmers Julia Vasconcellos Peixoto Rodrigo Gay Ducati José Fernando Ruggiero Bachega Leandro de Mattos Pereira Rafael Andrade Caceres Fernanda Majolo Guilherme Liberato da Silva Débora Bublitz Anton Odir Antônio Dellagostin João Antônio Pegas Henriques Léder Leal Xavier Márcia Inês Goettert Stefan Laufer SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions
description	Abstract Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, contributing towards studies of selective structure-based drug discovery and vaccine development.
format	article
author	Luis Fernando Saraiva Macedo Timmers Julia Vasconcellos Peixoto Rodrigo Gay Ducati José Fernando Ruggiero Bachega Leandro de Mattos Pereira Rafael Andrade Caceres Fernanda Majolo Guilherme Liberato da Silva Débora Bublitz Anton Odir Antônio Dellagostin João Antônio Pegas Henriques Léder Leal Xavier Márcia Inês Goettert Stefan Laufer
author_facet	Luis Fernando Saraiva Macedo Timmers Julia Vasconcellos Peixoto Rodrigo Gay Ducati José Fernando Ruggiero Bachega Leandro de Mattos Pereira Rafael Andrade Caceres Fernanda Majolo Guilherme Liberato da Silva Débora Bublitz Anton Odir Antônio Dellagostin João Antônio Pegas Henriques Léder Leal Xavier Márcia Inês Goettert Stefan Laufer
author_sort	Luis Fernando Saraiva Macedo Timmers
title	SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions
title_short	SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions
title_full	SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions
title_fullStr	SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions
title_full_unstemmed	SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions
title_sort	sars-cov-2 mutations in brazil: from genomics to putative clinical conditions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a38334c048754c499bd25a4e0e1ff844
work_keys_str_mv	AT luisfernandosaraivamacedotimmers sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT juliavasconcellospeixoto sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT rodrigogayducati sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT josefernandoruggierobachega sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT leandrodemattospereira sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT rafaelandradecaceres sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT fernandamajolo sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT guilhermeliberatodasilva sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT deborabublitzanton sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT odirantoniodellagostin sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT joaoantoniopegashenriques sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT lederlealxavier sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT marciainesgoettert sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions AT stefanlaufer sarscov2mutationsinbrazilfromgenomicstoputativeclinicalconditions
_version_	1718379183935062016

SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions

Ejemplares similares